Carbonyldifluorid

2.896 g/l

PUNGENT, VERY HYGROSCOPIC GAS; DENSITY (SOLID) @ -190 °C: 1.388; HEAT OF FORMATION: 166.6 KCAL; INSTANTLY HYDROLYZED BY WATER

Density (gas): 2.89 g/l

Relative density (water = 1): 1.39 (-190 °C)

2.698 g/L

2.29(relative gas density)

COLORLESS GAS

Colorless gas [Note: Shipped as a liquefied compressed gas].

Reacts with water (NIOSH, 2024)

Hygroscopic

Solubility in water: reaction

Reacts

-117 °F at 760 mmHg (USCG, 1999)

-84.57 °C

-83 °C

-118 °F

-84.57 °C @760 [mm Hg]

-118 °F

DECOMP IN WATER AND ALC

When heated to decomp it emits toxic fumes of carbon monoxide and ... /hydrogen fluoride/.

450-490 °C. This produces toxic gases. Reacts with water and moist air.

-173 °F (USCG, 1999)

-111.26 °C

-114 °C

-173 °F

-111.26 °C

-173 °F

1.139 at -173.2 °F (USCG, 1999) - Heavier than air; will sink (Relative to Air)

Relative vapor density (air = 1): 2.3

1.139 at -173.2 °F

55.4 atm (NIOSH, 2024)

4.45X10+4 mm Hg at 25 °C /calculated from experimentally derived coefficients/

55.4 atm

55.4 atm

13.02 eV

13.02 eV

Carbonyl fluoride appears as a colorless gas with a pungent odor. Very toxic by inhalation. Prolonged exposure of the containers to fire or heat may result in violent rupturing and rocketing.

Colorless gas with a pungent and very irritating odor; Note: Shipped as a liquefied compressed gas; [NIOSH]

COLOURLESS HYGROSCOPIC COMPRESSED LIQUEFIED GAS WITH PUNGENT ODOUR.

Colorless gas with a pungent and very irritating odor.

Colorless gas with a pungent and very irritating odor. [Note: Shipped as a liquefied compressed gas.]

Danger

H280 (81.1%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]；H290 (18.3%): May be corrosive to metals [Warning Corrosive to Metals]；H314 (99.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H330 (81.7%): Fatal if inhaled [Danger Acute toxicity, inhalation]；H331 (18.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]

P234, P260, P261, P264, P271, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P363, P390, P403+P233, P405, P406, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 169 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

S - indicates a substance that is identified in a final Significant New Use Rule.

Status: Active Update: 01-02-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22114

Carbonyl fluoride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Toxic gas is generated when heated. (USCG, 1999)

· Some may burn but none ignite readily.；· Vapors from liquefied gas are initially heavier than air and spread along ground.；· Some of these materials may react violently with water.；· Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices.；· Containers may explode when heated.；· Ruptured cylinders may rocket.；· For UN1005: Anhydrous ammonia, at high concentrations in confined spaces, presents a flammability risk if a source of ignition is introduced.

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

Irritates lungs, causing delayed pulmonary edema. Slight gassing produces dryness or burning sensation in the throat, numbness, pain in the chest, bronchitis, and shortness of breath. (USCG, 1999)

· TOXIC and/or CORROSIVE; may be fatal if inhaled, ingested or absorbed through skin.；· Vapors are extremely irritating and corrosive.；· Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.；· Fire will produce irritating, corrosive and/or toxic gases.；· Runoff from fire control or dilution water may cause environmental contamination.

Liquid is a severe skin irritant; [CHRIS] Toxic effects from the liberation of fluoride by hydrolysis; causes pulmonary edema in animals exposed to lethal concentrations and liver and kidney damage in subchronic studies; Critical Effects are irritation; bone; fluorosis. [ACGIH] Possible frostbite from contact with liquid; [NIOSH] See FLUORIDES.

2417 125

2417 125

U033; As stipulated in 40 CFR 261.33, when carbon oxyfluoride, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

CARBONYL FLUORIDE is an acid fluoride. Incompatible with water, with bases (including amines), with strong oxidizing agents, with alcohols. Reacts violently with hexafluoroisopropylideneaminolithium. High temperature causes decomposition to toxic carbon monoxide gas and fluorine. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:；SMALL FIRE: Dry chemical or CO2.；LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Do not get water inside containers. Damaged cylinders should be handled only by specialists.；FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.；· Keep unauthorized personnel away.；· Stay upwind, uphill and/or upstream.；· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).；· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.；· Stop leak if you can do it without risk.；· If possible, turn leaking containers so that gas escapes rather than liquid.；· Prevent entry into waterways, sewers, basements or confined areas.；· Do not direct water at spill or source of leak.；· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.；· Isolate area until gas has dispersed.

Excerpt from NIOSH Pocket Guide for Carbonyl fluoride:；Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.；Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.；Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:；· Call 911 or emergency medical service.；· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.；· Move victim to fresh air if it can be done safely.；· Administer oxygen if breathing is difficult.；· If victim is not breathing:；-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.；-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).；-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.；· Remove and isolate contaminated clothing and shoes.；· For minor skin contact, avoid spreading material on unaffected skin.；· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.；· For severe burns, immediate medical attention is required.；· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.；· Keep victim calm and warm.；· Keep victim under observation.；· For further assistance, contact your local Poison Control Center.；· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.；Specific First Aid:；· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

(General first aid procedures)；Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.；Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.；Breathing: Respiratory support

· Wear positive pressure self-contained breathing apparatus (SCBA).；· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.；· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.

Environmental considerations: land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3).

Environmental considerations @!@ water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Add soda ash (NaCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Hydrofluoric acid solution/

Environmental considerations @!@ air spill: Apply water spray or mist to knock down vapors.

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:；Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Isolate area until gas has dispersed. (ERG, 2024)

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U033, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

If material not involved in fire: Attempt to stop leak if without undue personnel hazard. Do not use water. Neutralize spilled material with crushed limestone, soda ash, or lime.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. If contact with the material anticipated, wear appropriate chemical protective clothing.

Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

The substance can be absorbed into the body by inhalation of the gas.

inhalation, skin and/or eye contact

Burning sensation. Sore throat. Cough. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Pain. ON CONTACT WITH LIQUID: FROSTBITE.

Redness. Pain. ON CONTACT WITH LIQUID: FROSTBITE.

irritation eyes, skin, mucous membrane, respiratory system; eye, skin burns; lacrimation (discharge of tears); cough, pulmonary edema, dyspnea (breathing difficulty); chronic exposure: gastrointestinal pain, muscle fibrosis, skeletal fluorosis; liquid: frostbite

... 32 PPM OF CARBONYL DIFLUORIDE GIVEN IN 5 DAILY 1-HR EXPOSURES /TO RATS/ CAUSED A URINARY FLUORIDE INCR TO 42 MG/L, IN VIVO HYDROLYSIS & SUBSEQUENT METABOLIC EFFECTS, WHICH RESULTED IN LETHAL EFFECT OBSERVED, SUBSTANTIATES THE CONCLUSION THAT THE CAUSE OF TOXIC RESPONSE WAS INDEED DUE TO FLUORIDE-ION GENERATED BY HYDROLYSIS.

... Twenty female and 20 male rats received sublethal, 1-hour, daily inhalation exposures of polytetrafluoroethylene pyrolysis products at 52, 43, 29, 25, and 9 ppm of carbonyl fluoride. Nine rats (22%) died during or shortly after completion of the five 1-hour exposures. The signs of toxicity preceding death indicated extreme malaise and weakness in the rats. The fluoride in the urine of the exposed rats increased from 3 to 42 mg/L in 5 days. Protein, glucose, ketones, and occult blood were detected in the urine. The succinic dehydrogenase activity in the kidney was inhibited to less than 5% of its normal value. The lung tissue reacted after the fifth day of exposure to produce increased amounts of succinic dehydrogenase enzyme to compensate for the fluoride inhibitory effect. The liver of exposed rats showed enlarged nuclei and fatty infiltration of the cells. Marked body weight loss (30%) occurred subsequent to exposures, indicating that metabolism was inhibited. The significant increase in the urinary fluoride coincident with the period of weight loss and the period of weight recovery coincident with the elimination of fluoride are evidence for a cause and effect relationship between fluoride toxicity and the body metabolism. Although severe injury was inflicted on the rats, the metabolic inhibition observed was completely reversible, and with the exception of a small amount of emphysematous changes, all previously mentioned pathologic changes in the lungs, the liver, and the kidneys were reversible within 18 days following exposure. Based on these results, the authors concluded that the toxic syndrome of carbonyl fluoride inhalation present in the pyrolysis product of polytetrafluoroethylene is compatible with descriptions of hydrogen fluoride poisoning.

... /Authors/ studied the pathological changes produced in the respiratory tract of dogs, rabbits, guinea pigs, mice, and rats exposed to carbonyl fluoride. In this experiment, rats were sacrificed over a period of 3 weeks following a single, 1-hour exposure at 310 ppm. The lungs of rats sacrificed 24 hours after exposure showed focal hemorrhage and pulmonary edema. Similar effects were seen in the other animal species that were sacrificed following exposure. A 48-hour, postexposure picture of the lung of a rat showed rapid cellular reorganization and clearing of edema from the lung. The alveolar damage did not resolve as readily. In general, extravasation of red cells from damaged capillaries proceeded for 3 or 4 days but usually stopped before 7 days. Some residual focal emphysema was left as the final, irreversible lesion with only a small amount of mild interstitial fibrosis.

... /Authors/ evaluated the acute inhalation toxicity of carbonyl fluoride to rats. The LC50 determinations were for a 1 hr exposure followed by a 14 day, postexposure, observation period. Each test group consisted of 10 rats, 5 female and 5 male. To determine the effects of age, test groups of both 8- and 24-week old rats were used. The LC50 values for the 8- and 24-week-old rats were 360 and 460 ppm, respectively. The results of this study indicated that young rats were more susceptible than older rats to the toxic action of carbonyl fluoride. To determine the effect of exposure duration, a test group of 8-week-old rats was exposed at 90 ppm of carbonyl fluoride for 4 hours. The mortality was equal to that in the LC50 obtained in the 1-hour exposure at 360 ppm of carbonyl fluoride. This mortality indicates that the lethal effect is a function of the exposure concentration (C) times the time (t) of exposure, and that this exposure-concentration range (Ct), 1-4 hours, is a constant. No significant difference in mortality between the sexes was observed. The deaths produced usually occurred in 24-48 hours after termination of exposure.

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Effects may be delayed. Obtain medical attention. /Hydrofluoric acid and related compounds/

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Monitor for shock and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Hydrofluoric acid and related compounds/

Treatment /of acute poisoning/ includes the iv admin of glucose in saline and gastric lavage with lime water (0.15% calcium hydroxide soln) or other Ca+2 salts to precipitate the fluoride. Calcium gluconate is given iv for tetany; urine volume is kept high with vigorous fluid resuscitation. /Fluoride/

S - indicates a substance that is identified in a final Significant New Use Rule.

Status: Active Update: 01-02-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22114

Carbonyl fluoride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

U033; As stipulated in 40 CFR 261.33, when carbon oxyfluoride, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Carbonyl fluoride

12

45

Weapons of Mass Effect chemical material that, if stolen or diverted, can be converted into weapons using simple chemistry, equipment, or techniques.

/Studies in man revealed/ peak serum levels are reached within a half hour, and levels fall promptly, with 20% of a given dose being excreted in the urine within 4 hr. /Fluoride/

FLUORIDES ARE ABSORBED FROM GI TRACT, LUNG, & SKIN. GI TRACT IS MAJOR SITE OF ABSORPTION. THE RELATIVELY SOL CMPD, SUCH AS SODIUM FLUORIDE, ARE ALMOST COMPLETELY ABSORBED. ... FLUORIDE HAS BEEN DETECTED IN ALL ORGANS & TISSUES, AND IT IS CONCENTRATED IN BONE, THYROID, AORTA, & PERHAPS KIDNEY. FLUORIDE IS PRIMARILY DEPOSITED IN BONE & TEETH, & THE DEGREE OF SKELETAL STORAGE IS RELATED TO INTAKE AND AGE. ... MAJOR ROUTE OF ... EXCRETION IS VIA THE KIDNEYS; ... /ALSO EXCRETED IN SMALL AMT/ IN SWEAT, MILK, AND INTESTINAL SECRETIONS. ... ABOUT 90% OF FLUORIDE ION FILTERED BY GLOMERULUS IS REABSORBED BY RENAL TUBULES. /FLUORIDE/

/RENAL CLEARANCE/ 1. VIRTUALLY ALL FLUORIDE IN PLASMA ... IS ULTRAFILTERABLE. 2. RENAL EXCRETION OF RADIOFLUORIDE DEPENDS ON GLOMERULAR FILTRATION & VARIABLE TUBULAR REABSORPTION. 3. PROBABLY, REABSORPTION IS LARGELY PASSIVE ... 4. FLUORIDE EXCRETION INCR WHEN PLASMA CONCN IS INCREASED. 5. PROCEDURES THAT INCREASE URINARY FLOW RATE (EG, ADMIN OF OSMOTIC DIURETICS, HYPERTONIC SALINE, OR DIURETIC DRUGS) INCREASE THE CLEARANCE OF FLUORIDE. /FLUORIDE/

RATS GIVEN (18)FLUORIDE ION AS A RADIOTRACER BY CONTINUOUS IV INFUSION OF SODIUM FLUORIDE FOR 3 HR SHOWED AT SUBLETHAL DOSE RATES, BLOOD FLUORIDE CONCN NEARS STEADY STATE PROPORTIONAL TO FLUORIDE INFUSION RATE. BLOOD, KIDNEY, & LUNG HAD HIGHEST CONCN @ DOSES UP TO 3 MG FLUORIDE/KG/HR, BUT @ 6 MG/KG/HR THE FLUORIDE OF THE LIVER, SPLEEN & HOLLOW ORGANS INCR SHARPLY. AMT ABOVE THIS WAS NOT WELL PROCESSED BY EXCRETORY MECHANISM. RATS INFUSED 3 HR WITH 6 MG FLUORIDE/KG/HR: DURING INFUSION FLUORIDE CONCN OF BONE & OTHER TISSUES WAS HIGH, BONE THE HIGHEST. OF SOFT TISSUES, LUNG HAD THE HIGHEST, BRAIN, TESTES, & FAT PADS THE LEAST CONCN. DURING DEPLETION PHASE, TISSUE FLUORIDE CONCN DECR, BONE FLUORIDE REMAINED CONSTANT, & SUBSTANTIAL AMOUNT REMAINED IN THE LUNG. /FLUORIDE/

For more Absorption, Distribution and Excretion (Complete) data for CARBONYL DIFLUORIDE (11 total), please visit the HSDB record page.

Used in organic synthesis; generated from the thermal degradation of fluoropolymers, e.g., polytetrafluoroethylene (PTFE) and polyfluoroethylenepropylene; [ACGIH]

CHEM INT IN ORG SYNTH, EG, FLUORINATED ALKYL ISOCYANATES.

Suggested for use as a military poison gas.

Organic synthesis

ACTION OF SILVER FLUORIDE ON CARBON MONOXIDE.

FROM CARBON MONOXIDE AND FLUORINE OR BROMINE TRIFLUORIDE AND CARBON MONOXIDE.

REACTION OF PHOSGENE WITH SODIUM FLUORIDE AND HYDROGEN CYANIDE.