HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Fluorpyridin
2-CYANOPHENYLBORONIC ACID · 2-Fluoropyride · 2-Fluorpyridin · o-fluoropyridine · 2-FLUOROPYRIDINE · 2-fluoro-pyridin · 2-Fluoroypyridine · 2-Fluorpyridin CAS
Identifikatoren & physikalische Daten
| CAS No. | 372-48-5 |
|---|---|
| Summenformel | C5H4FN |
| Durchschnittliche Molmasse | 97,09 g/mol |
| Monoisotopische Masse | 97,03277735 g/mol |
| SMILES | Fc1ccccn1 |
| InChIKey | MTAODLNXWYIKSO-UHFFFAOYSA-N |
| PubChem CID | 9746 |
| ChEMBL | CHEMBL1162360 |
| EC No. | 206-757-5 |
| DTXSID | DTXSID70190689 |
| Lokaler Name | 2-Fluorpyridin |
Chemische & physikalische Eigenschaften
| XLogP | 0,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 12,9 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 7 |
| Formalladung | 0 |
| Komplexität | 56 |
| Stoffklassen | Nitrogen Compounds -> Pyridines |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| LogP (Verteilungskoeffizient) | 0.84 |
| Dampfdruck | 26.6 [mmHg] |
| Physical Description | Clear dark brown liquid[Sigma-Aldrich MSDS] |
| Siedepunkt | 126 °C/753 mmHg (lit.) |
| Dichte | 1.128 g/mL at 25 °C (lit.) |
| Brechungsindex | n20/D 1.466(lit.) |
| Flammpunkt | 83 °F |
| Lagerbedingungen | Inert atmosphere,2-8°C |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | -0.44(at 25℃) |
| Farbe | Clear colorless to light yellow |
| Wichte | 1.13 |
| Löslichkeit | Soluble in water. |
| BRN | 1515 |
| Dielektrizitätskonstante | 37.289999999999999 |
| InChI | InChI=1S/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H |
| InChIKey | MTAODLNXWYIKSO-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=CC=C1 |
| CAS Datenbank | 372-48-5(CAS DataBase Reference) |
| NIST chemische Informationen | 2-Fluoropyridine(372-48-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH226 (100%): Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 50 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | 2-Fluoropyridine: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | A skin and strong eye irritant[Sigma-Aldrich MSDS] |
| Hazard Classes and Categories | Flam. Liq. 3 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 1993 3/PG 3 |
| Zollcode | 29333999 |
| RTECS-Nr. | UT3900000 |
| R-Sätze (R) | 10-36/37/38-20/21/22 |
| Gefahrensymbole | Xi,F,Xn |
| hazard_note | Flammable/Irritant |
| Sicherheitshinweise (S) | 26-36-36/37/39-16 |
| Gefahrenklasse | 3Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3 |
| Verpackungsgruppe | III |
| Lagerklasse | 3 - Flammable liquids |
Anwendungen & Verwendung
Verwenden
2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.