clasto-Lactacystin beta-lactone
Grundinformationen
- CAS
154226-60-5- Standard-SMILES
CC(C)[C@H](O)[C@@]12NC(=O)[C@H](C)[C@@H]1OC2=O- InChIKey
FWPWHHUJACGNMZ-NBBQQVJHSA-N- Summenformel
- C10H15NO4
- Durchschnittliche Molmasse
- 213,23 g/mol
- Monoisotopische Masse
- 213,10010796
Überblick
active metabolite of lactacystin; inhibits 20 S proteasome; structure in first source
Namen und Bezeichner
- Bevorzugter Name
- clasto-Lactacystin beta-lactone
- IUPAC
- (1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
- Englischer Name
- Clasto-Lactacystin ?-lactone
- Summenformel
- C10H15NO4
- Molmasse
- 213.23
Namen und Synonyme
clasto-lactacystin beta-lactonec-lact compound(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione(1R,4R,5S)-1-((1S)-1-hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dioneRefChem:918778664-305-6Omuralide154226-60-5clasto-Lactacystin |A-lactone(-)-Omuralide6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-Omuralide?
Weitere Namen anzeigen
clasto-lactacystin β-lactoneBETA-CLASTOLACTACYSTINClasto-lactacystin (OMuralide)LACTACYSTIN, CLASTO-, BETA-LACTONEclasto-Lactacystin β-Lactoneclasto-Lactacystin beta-lactone, 20S proteasome inhibitor1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
CHEMBL381627SCHEMBL8234083GLXC-15280BDBM50590311MFCD01076526(1S,2R,5R)-5-[(1S)-1-hydroxy-2-methylpropyl]-2-methyl-7-oxa-4-azabicyclo[3.2.0]heptane-3,6-dioneHY-108549CS-0029132
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,7
- Polarare Oberfläche (TPSA)
- 75,6 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 15
- Formalladung
- 0
- Komplexität
- 327
Physikochemische Eigenschaften
- Schmelzpunkt
- 186 · 186-187°C
- Siedepunkt
- 440.815 · 440.815±40.00 °C(Press: 760.00 Torr)(predicted)
- Dichte
- 1.28 · 1.280±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
- Aggregatzustand
- White solid
- pka
- 13.332 · 13.332±0.20(predicted)
- Farbe
- White
- InChI
- 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
- InChIKey
- FWPWHHUJACGNMZ-NBBQQVJHSA-N
- SMILES
- [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Sicherheitsdaten
- wgk
- 2
- ridadr
- UN 2811 6.1 / PGIII
- risk_code
- 20/21/22-37/38-41-36/37/38-25
- hazard_code
- T
- safety_code
- 16-26-36/37/39-45
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationExogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
Anwendungen
VerwendenA cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter12 Anbieter
MedBio脉铂医药021-69568360 18916172912 · [email protected]
AdooQ BioScience, LLC+1 (866) 930-6790 · [email protected]
ApexBio Technology LLC+1-832-696-8203 · [email protected]
凯试（上海）科技有限公司021-50135380 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…