Pridopidine
Grundinformationen
- CAS
346688-38-8- Standard-SMILES
CCCN1CCC(c2cccc(S(C)(=O)=O)c2)CC1- InChIKey
YGKUEOZJFIXDGI-UHFFFAOYSA-N- Summenformel
- C15H23NO2S
- Durchschnittliche Molmasse
- 281,4 g/mol
- Monoisotopische Masse
- 281,14495015
Überblick
ACR-16 is under investigation by NeuroSearch. ACR16 has been successfully investigated in a Phase II multi-centre, randomised and placebo-controlled trial in patients with Huntington’s disease as well as in three Phase Ib studies within Huntington’s disease, Parkinson’s disease and schizophrenia respectively. ACR-16 is a dopamine stabilizer. ACR-16 is also being studied in other psychiatric and neurologic diseases.
Namen und Bezeichner
- Bevorzugter Name
- Pridopidine
- IUPAC
- 4-(3-methylsulfonylphenyl)-1-propylpiperidine
- Englischer Name
- 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
- Summenformel
- C15H23NO2S
- Molmasse
- 281.41
Namen und Synonyme
PRIDOPIDINE346688-38-84-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidineACR-16ACR16ACR16 compoundHuntexilPridopidinapridopidinumHD4TW8S2VK4-(3-methanesulfonylphenyl)-1-propylpiperidine
Weitere Namen anzeigen
ASP 2314FR 310826Pridopidine, 10 mM in DMSO4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine
DTXSID90188225RefChem:868501DTXCID201107164-(3-Methylsulfonylphenyl)-1-propylpiperidineACR 16UNII-HD4TW8S2VKPridopidine [USAN:INN]MFCD09835586
Datenbank-Bezeichner
- CAS
346688-38-8- PubChem CID
- 9795739
- DTXSID
DTXSID90188225- ChEMBL
CHEMBL596802- UNII
- HD4TW8S2VK
- EC Number
- 810-806-1
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,6
- Polarare Oberfläche (TPSA)
- 45,8 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 19
- Formalladung
- 0
- Komplexität
- 366
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
Physikochemische Eigenschaften
- Schmelzpunkt
- 73 · 73-750C
- Siedepunkt
- 434.2 · 434.2±45.0 °C(Predicted)
- Dichte
- 1.092 · 1.092±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- Soluble in DMSO (up to 10 mg/ml).
- pka
- 9.09 · 9.09±0.10(Predicted)
- Aggregatzustand
- solid
- Farbe
- White
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
- InChIKey
- YGKUEOZJFIXDGI-UHFFFAOYSA-N
- SMILES
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Sicherheitsdaten
- wgk
- WGK 3
- hs_code
- 2933399090
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
ATC Code
N - Nervous system
QN - Nervous system
Mechanism of Action
ACR16 belongs to a novel class of drugs, characterised as dopaminergic stabilisers, CNS active compounds that can both enhance and counteract dopaminergic effects in the brain depending on the initial level of dopaminergic activity. ARC16 works to "smooth" the many functions of this neurotransmitter chemical in striatum and other areas of the brain. Thus they have the ability to stabilize behavioural and motor disturbances caused by neurological and psychiatric disorders. They do this in pathological states without compromising normal thought processes or motor functions.
Anwendungen
Verwenden4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine is a new modulator of dopamine neurotransmission. Dopamine is a neurotransmitter in the brain. Drugs that act at central dopamine receptors are commonly used in the treatment of neurologic and psychiatric disorders.
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