Pseudoephedrine Sulfate
Grundinformationen
- CAS
7460-12-0- Standard-SMILES
CN[C@@H](C)[C@@H](O)c1ccccc1.CN[C@@H](C)[C@@H](O)c1ccccc1.O=S(=O)(O)O- InChIKey
CAVQBDOACNULDN-NRCOEFLKSA-N- Summenformel
- C20H32N2O6S
- Durchschnittliche Molmasse
- 428,5 g/mol
- Monoisotopische Masse
- 428,19810792
Überblick
Pseudoephedrine Sulfate is the sulfate salt form of pseudoephedrine, a phenethylamine and a diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine sulfate displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.
Namen und Bezeichner
- Bevorzugter Name
- Pseudoephedrine Sulfate
- IUPAC
- bis((1S,2S)-2-(methylamino)-1-phenylpropan-1-ol);sulfuric acid
Namen und Synonyme
Pseudoephedrine sulfate7460-12-0AfrinolSch 4855D-Isoephedrine sulfatepseudoephedrine sulphated-Pseudoephedrine sulfateY9DL7QPE6BSCH-4855(+)-pseudoephedrine sulfate(+)-PSEUDOEPHEDRINE SULPHATEDISOBROM COMPONENT PSEUDOEPHEDRINE SULFATE
Weitere Namen anzeigen
DRIXORAL COMPONENT PSEUDOEPHEDRINE SULFATERESPORAL COMPONENT PSEUDOEPHEDRINE SULFATETRINALIN COMPONENT PSEUDOEPHEDRINE SULFATEDISOPHROL COMPONENT PSEUDOEPHEDRINE SULFATEBROMPHERIL COMPONENT PSEUDOEPHEDRINE SULFATECLARINEX-D COMPONENT PSEUDOEPHEDRINE SULFATECLARITIN-D COMPONENT PSEUDOEPHEDRINE SULFATEDRIXORAL PLUS COMPONENT PSEUDOEPHEDRINE SULFATE
Datenbank-Bezeichner
- CAS
7460-12-0- PubChem CID
- 9802673
- DTXSID
DTXSID20889379- ChEMBL
CHEMBL3989855- UNII
- Y9DL7QPE6B
- EC Number
- 231-243-2
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 148 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 202
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 198 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationREACH registered substance: Bis[[S-(R*,R*)]-(β-hydroxy-α-methylphenethyl)methylammonium] sulphate (EC: 231-243-2)
Other Safety InformationIMAP assessments - Benzenemethanol, .alpha.-[1-(methylamino)ethyl]-, [S-(R*,R*)]-, sulfate (2:1) (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxikologische Informationen
Exposure RoutesPseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Toxicity Summary
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.
Chemie und Industrie
Pharmakologische Informationen
Metabolism/MetabolitesHepatic.
Half Life: 9-16 hours
Verwendung und Herstellung
Uses
For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
General Manufacturing InformationBenzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.S)-, sulfate (2:1): ACTIVE
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