GW 501516

HCID 9803963CAS 317318-70-0

Grundinformationen

Standard-SMILES
Cc1cc(SCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)O
InChIKey
YDBLKRPLXZNVNB-UHFFFAOYSA-N
Summenformel
C21H18F3NO3S2
Durchschnittliche Molmasse
453,5 g/mol
Monoisotopische Masse
453,0680201

Überblick

GW 501516 is an aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively. It has a role as a carcinogenic agent and a PPARbeta/delta agonist. It is a monocarboxylic acid, an aromatic ether, an aryl sulfide, an organofluorine compound and a member of 1,3-thiazoles.

Namen und Bezeichner

Bevorzugter Name
GW 501516
IUPAC
2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
Englischer Name
GW-501516
Summenformel
C21H18F3NO3S2
Molmasse
453.5

Namen und Synonyme

317318-70-0EndurobolGW 501516GW501516GW-501516GSK-516GW1516GW-15167I2HA1NU222-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acidDTXSID3041037
Weitere Namen anzeigen
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic AcidCS-788CARDAROLGW-501615CardrarineGW501516 20mg
CHEBI:73726(2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methylsulfanyl)phenoxy)acetic acidRefChem:574663DTXCID1021037CardarineUNII-7I2HA1NU22GW 1516

Datenbank-Bezeichner

CAS
317318-70-0
PubChem CID
9803963
DTXSID
DTXSID3041037
ChEMBL
CHEMBL38943
ChEBI
CHEBI:73726
UNII
7I2HA1NU22
Nikkaji
J1.561.880I

Eigenschaften

Berechnete Struktureigenschaften

XLogP
5,9
Polarare Oberfläche (TPSA)
113 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
9
Frei drehbare Bindungen
7
Schwere Atome
30

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Listed in ZINC15

Physikochemische Eigenschaften

Schmelzpunkt
134 · 134-136°C
Siedepunkt
584.5 · 584.5±60.0 °C(Predicted)
Dichte
1.42 · 1.42±0.1 g/cm3(Predicted)
storage temp.
-20 °C · -20°C
Löslichkeit
20 mg/mL, · DMSO: soluble20mg/mL, clear
Aggregatzustand
powder

Sicherheit und Regulatorisches

Sicherheitsdaten

wgk
3
RTECS-Nr.
AI9105500
Speicherklasse
11 - Combustible Solids

Chemie und Industrie

Pharmakologische Informationen

Mechanism of Action · 1 Eintrag

This drug regulates fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. Overexpression of PPARdelta using a transgenic murine model promotes an increase of muscle oxidative capability. It also plays a major role in the metabolic adaptations to western diet characterized by an excessive amount of saturated fat.

Anwendungen · 3 Einträge

BeschreibungGW501516, also known as GW-1516 or cardarine and endurobol, is a peroxisome proliferator-activated receptor delta (PPAR-δ) agonist. Activation of the receptor will increase fat-burning capacity and muscle production, as it changes the body's fuel preference from glucose to lipids.

HistoryGW501516, also known as Cardarine, was originally discovered in the early 1990s during a research collaboration between two large pharmaceutical companies. The initial proposed use was for the treatment of hyperlipidemia (elevated fats in the blood), though later studies looked at its effectiveness for treating obesity, diabetes, and cardiovascular disease.

VerwendenAn experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist. Exhibits selectivity for PPARd compared t

Anbieter50 Anbieter

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
江西泰欣诺实业有限公司13576915071 · [email protected]
Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.

Zugehörige Reaktionen

5

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