Advair
Grundinformationen
- CAS
136112-01-1- Standard-SMILES
CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C.OCc1cc(C(O)CNCCCCCCOCCCCc2ccccc2)ccc1O- InChIKey
YYAZJTUGSQOFHG-RZFXJYHSSA-N- Summenformel
- C50H68F3NO9S
- Durchschnittliche Molmasse
- 916,1 g/mol
- Monoisotopische Masse
- 915,45668841
Namen und Bezeichner
- Bevorzugter Name
- Advair
- IUPAC
- [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
- Englischer Name
- 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
- Summenformel
- C50H68F3NO9S
- Molmasse
- 0
Namen und Synonyme
AdvairRefChem:915195viani136112-01-1Fluticasone/salmeterolSCHEMBL3989orb1679082TP2406Q581334Advair DiskusAdoairSeretide
Weitere Namen anzeigen
Adoair DiskusFlutide DiskusSeretide AccuhalerSalMeterol-fluticasone propionate Mixt.SalMeterol Fluticasone Propionate Mixture[(6S,8S,10S,11S,13S,14S,16R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid S-(FluoroMethyl) Ester Mixture with 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol
Datenbank-Bezeichner
- CAS
136112-01-1- PubChem CID
- 9811567
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 188 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 14
- Frei drehbare Bindungen
- 22
- Schwere Atome
- 64
- Formalladung
- 0
- Komplexität
- 1.390
Physikochemische Eigenschaften
- InChI
- InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2
- InChIKey
- GIIZNNXWQWCKIB-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Anwendungen
VerwendenSalmeterol-fluticasone combination as Adoair, dry powder inhlaler/pressured metered-dose inhaler formulation for bronchial asthma, its benefit or demerits as device for inhalation drug delivery system in pharmacokinetics/pharmacodynamics at lung or peripheral bronchi, indications and usage of aerochamber, and clinical efficacy and safety in asthma control.
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