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Zinkhydroxid

Zinc Hydroxide

HCID 9812759
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Grundinformationen

CAS
20427-58-1
Standard-SMILES
[OH-].[OH-].[Zn+2]
InChIKey
UGZADUVQMDAIAO-UHFFFAOYSA-L
Summenformel
H2O2Zn
Durchschnittliche Molmasse
99,4 g/mol
Monoisotopische Masse
97,934621

Überblick

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Hydroxide...

Namen und Bezeichner

Bevorzugter Name
Zinc Hydroxide
IUPAC
zinc dihydroxide
Lokaler Name
Zinkhydroxid
Englischer Name
Zinc hydroxide
Summenformel
H2O2Zn
Molmasse
99.41

Namen und Synonyme

ZINC HYDROXIDEZinc dihydroxideOXK3V8KJ7LDTXSID7042516RefChem:904951zinc(2+) ion dihydroxideDTXCID5022516243-814-320427-58-1Zinc hydroxide (Zn(OH)2)ZINCHYDROXIDEMFCD00049620
Weitere Namen anzeigen
znmc hydroxideZinc dihydoxidezincdihydroxidezinchydroxide(zn(oh)2)Zinc oxide ammonia complexZinc hydroxide≥ 99% (Assay)ZINC HYDROXIDE ISO 9001:2015 REACH
Zinc hydroxide [VANDF]SCHEMBL19509AKOS015833777NS00084213F510145Q204820

Datenbank-Bezeichner

CAS
20427-58-1
PubChem CID
9812759
DTXSID
DTXSID7042516
UNII
OXK3V8KJ7L
EC Number
243-814-3
Nikkaji
J134.217G

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
2 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
0
Schwere Atome
3
Formalladung
0
Komplexität
0

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Metals, Inorganic Compounds
CosmeticsCosmetic ingredients (Zinc Hydroxide) -> CIR (Cosmetic Ingredient Review)
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical Description · 2 Einträge

Liquid; Wet Solid

Colorless solid; [Hawley] White odorless powder; [MSDSonline]

Physikochemische Eigenschaften

Schmelzpunkt
125 · 125, decomposes [HAW93]
Dichte
3.05 · 3.050
Dampfdruck
0 Pa · 0Pa at 20℃
storage temp.
Store at room temperature, keep dry and cool
Aggregatzustand
colorless orthorhombic crystals
Farbe
colorless orthorhombic crystals, crystalline
PH
8.88 · 8.88(1 mM solution);8.88(10 mM solution);8.88(100 mM solution)

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 3.2% (11 of 348) of reports.

Warning

H315 (18.1%): Causes skin irritation [Warning Skin corrosion/irritation]

P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 348 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Zinc hydroxide (Zn(OH)2)

Zinc hydroxide (Zn(OH)2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Zinc hydroxide (Zn(OH)2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Zinc hydroxide (EC: 243-814-3)

Zinc hydroxide: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryAn irritant; [MSDSonline] See Zinc.
Hazard Classes and CategoriesSkin Irrit. 2 (18.1%)

Sicherheit und Schutzausrüstung

Exposure Control and Personal Protection0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)]
Minimum Risk Level

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

Verwendung und Herstellung

Uses · 3 Einträge

CIR ingredient: Zinc Hydroxide

Used in chemical production, surgical dressings (absorbent), and rubber compounding; [Hawley]

Zinc hydroxide is used in surgical dressings. (L68)

U.S. Production2023: 5,000,000 - <10,000,000 lb
Consumer UsesSoil amendments (fertilizers)
Industry UsesOther
General Manufacturing Information · 2 Einträge

Miscellaneous Manufacturing

Zinc hydroxide (Zn(OH)2): ACTIVE

Anwendungen

VerwendenIntermediate, absorbent in surgical dressings, rubber compounding.

Darstellung

synthetischeThe compound is prepared by adding a strong alkali to a solution of zinc sulfate or chloride: ZnSO4 + 2NaOH → Zn(OH)2 + Na2SO4.

Zugehörige Reaktionen

8
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Reaktionsgleichung von HRID 593231
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Reaktionsgleichung von HRID 1158592
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Reaktionsgleichung von HRID 1808673
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Reaktionsgleichung von HRID 2035321
HRID 2035321als Eduktuspto-grants-2013_11

Notizen zur Verbindung

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Wasserlöslichkeit
2 O · slightly soluble H2O [HAW93]
Stabilität
Stable.
Kosmetik-Inhaltsstoffe Funktionen
ABSORBENT
InChI
InChI=1S/2H2O.Zn/h2*1H2;/q;;+2/p-2
InChIKey
UGZADUVQMDAIAO-UHFFFAOYSA-L
SMILES
[Zn](O)O
LogP
-1.38 · -1.380 (est)
CAS Datenbank
20427 · 20427-58-1(CAS DataBase Reference)
EPA chemische Informationen
Zinc hydroxide (20427-58-1)
Intermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)
Protective Action Criteria (PAC) · 3 Einträge

6.1 [mg/m3]

67 [mg/m3]

400 [mg/m3]

Toxikologische Informationen

TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)
Exposure RoutesInhalation (L49) ; oral (L49) ; dermal (L49)
Toxicity Summary · 3 Einträge

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Hydroxide...

Safe for use in cosmetics, with qualifications

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Signs and Symptoms · 1 Eintrag

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Sicherheitsdaten

tsca
TSCA listed

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

ZinksulfatNatriumhydroxid

Nachgelagerte Produkte

NatriumdithionatDibortrizinkhexaoxidNatriumdithionitZINC BORATE 3.5 HYDRATEBorsure, ZinksalzZinkoxidPyrimidin-2-ylamin4-Methoxy-6-methyl-1,3,5-triazin-2-aminbis(D-gluconato-O1,O2)zinkNatriumhydroxymethansulfinat