Polaprezinc
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Grundinformationen
- CAS
107667-60-7- Standard-SMILES
NCCC(=O)N[C@@H](Cc1c[n-]cn1)C(=O)[O-].[Zn+2]- Summenformel
- C9H12N4O3Zn
- Durchschnittliche Molmasse
- 289,61 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Polaprezinc
- Englischer Name
- Polaprezinc
- Summenformel
- C9H12N4O3Zn
- Molmasse
- 289.61
Namen und Synonyme
ZINC CARNOSINEZinc L-CarnosinePromacZ 103D01611POLAPREZINCPepZinGI(R)Promac (tn)PolyprezineZn Carnosine
Datenbank-Bezeichner
- CAS
107667-60-7- PubChem CID
- 9817450
- ChEMBL
CHEMBL3184454- EC Number
- 600-848-7
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 300 °C · >300°C
- Siedepunkt
- 177.5 °C · 177.5°C
- storage temp.
- Refrigerator
- Löslichkeit
- Aqueous Acid (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1/C9H14N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7H,1-3,10H2,(H3,11,12,13,14,15,16);/q;+2/p-2/t7-;/s3
- InChIKey
- IGXZLYMCFZHNKW-WMASNCOMNA-L
- SMILES
- [C@@H]1(C(=O)O[Zn]N1C(=O)CCN)CC1NC=NC=1 |&1:0,r|
- CAS Datenbank
- 107667 · 107667-60-7(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- WGK 3
- Toxizität
- LD50 in male, female mice, rats (mg/kg): 220, 165, 405, 422 i.p.; 758, 874, >5000, >5000 s.c.; 1269, 1331, 8441, 7375 orally (Matsuda)
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungPolaprezinc, a complex of zinc ion and L-carnosine, is an antiulcer agent launched in Japan. It is effective in promoting the healing of gastric ulcers in addition to preventing ulcer relapse. In rat studies, polaprezinc reduces the incidence of stomach lesions induced by ethanol. No effect was seen on ultrastructural damage or on cell proliferation and it appears that polaprezinc combines the cytoprotective effect of zinc with the ulcer healing properties of Lcarnosine. The in vivo antioxidative properties of polaprezinc has been suggested to be responsible for its protective effect against gastric mucosal injury. Recent studies revealed that polaprezinc is an activator of bone formetion and has inhibitory effect of bone resorption. This agent is thus able to prevent the deterioration of bone metabolism indicating its potential usefulness in the treatment of osteoporosis. Polaprezinc has also been claimed for the prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis or other hepatopathies caused by certain drugs, poisons and radiation.
VerwendenA novel anti-gastric ulcer agent
Anbieter100 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
苏州合生源生物医药科技有限公司13918488572 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
河北创之源生物科技有限公司13012111162 · [email protected]
陕西帕尼尔生物科技有限公司029-84385017; +8613259417953 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.
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