SC 57461
Grundinformationen
- CAS
423169-68-0- Standard-SMILES
CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(=O)O.Cl- InChIKey
SBBJJLDNKNNWFJ-UHFFFAOYSA-N- Summenformel
- C20H26ClNO3
- Durchschnittliche Molmasse
- 363,9 g/mol
- Monoisotopische Masse
- 363,1601214
Überblick
a leukotriene A4 hydrolase inhibitor; structure given in first source
Namen und Bezeichner
- Bevorzugter Name
- SC 57461
- IUPAC
- 3-[3-(4-benzylphenoxy)propyl-methylamino]propanoic acid;hydrochloride
- Englischer Name
- SC 57461A
- Summenformel
- C20H25NO3.ClH
- Molmasse
- 363.882
Namen und Synonyme
SC-57461ASC 57461SC-57461RefChem:181629423169-68-0SC 57461A3-(methyl(3-(4-(phenylmethyl)phenoxy)propyl)amino)propanoic acid3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride3-[3-(4-benzylphenoxy)propyl-methylamino]propanoic acid;hydrochlorideCHEMBL5434053-{[3-(4-BENZYLPHENOXY)PROPYL](METHYL)AMINO}PROPANOIC ACID HYDROCHLORIDEN-Methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-ss-alanine Hydrochloride; SC-57461 Hydrochloride
Weitere Namen anzeigen
SC-57461 HydrochlorideN-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochlorideinhibit,SC57461A,SC 57461A,Leukotriene A4,SC-57461A,Inhibitor,Aminopeptidase,orally active,LTA4 hydrolase
MFCD00951253orb1306233SCHEMBL1895851DTXSID801018101N-methyl-N-(3-(4-(phenylmethyl)phenoxy)propyl)-beta-alanineEX-A4985Tox21_500988AKOS024457432
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 49,8 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 10
- Schwere Atome
- 25
- Formalladung
- 0
- Komplexität
- 347
Physikochemische Eigenschaften
- Schmelzpunkt
- 163 · 163-165°C
- storage temp.
- 4 °C · Desiccate at +4°C
- Löslichkeit
- 5 mg/mL · DMSO: >5mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- InChI
- 1S/C20H25NO3.ClH/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17;/h2-4,6-11H,5,12-16H2,1H3,(H,22,23);1H
- InChIKey
- SBBJJLDNKNNWFJ-UHFFFAOYSA-N
- SMILES
- Cl.CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- risk_code
- 22-36/37/38
- hazard_code
- Xn
- safety_code
- 26
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2
Chemie und Industrie
Anwendungen
BeschreibungLeukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.
VerwendenSC 57461A is a potent and selective inhibitor of LTA4.
Anbieter39 Anbieter
苏州道澜生物医药科技有限公司15952404857 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
武汉易泰科技有限公司上海分公司
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