Cgc-11047
Grundinformationen
- CAS
206991-64-2- Standard-SMILES
CCNCCCNC/C=C\CNCCCNCC.Cl.Cl.Cl.Cl- InChIKey
VPYLLPVLWBWBLG-YSMBQZINSA-N- Summenformel
- C14H36Cl4N4
- Durchschnittliche Molmasse
- 402,3 g/mol
- Monoisotopische Masse
- 400,169408
Überblick
CGC-11047 is a polyamine analog designed to halt cell growth and induce apoptosis.
Namen und Bezeichner
- Bevorzugter Name
- Cgc-11047
- IUPAC
- (Z)-N,N'-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine;tetrahydrochloride
- Englischer Name
- SL 47
- Summenformel
- C14H33ClN4
- Molmasse
- 292.9
Namen und Synonyme
206991-64-2CGC-11047CGC 11047HU43305R7OSL 47RefChem:124760CGC11047SL 11047CDC 11047UNII-HU43305R7OPG-11047 (tetrahydrochloride)(Z)-N1,N1'-(but-2-ene-1,4-diyl)bis(N3-ethylpropane-1,3-diamine) tetrahydrochloride
Weitere Namen anzeigen
SL-11047(Z)-N,N'-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine:tetrahydrochloride
2-Butene-1,4-diamine, N,N'-bis(3-(ethylamino)propyl)-, tetrahydrochloride, (Z)-(Z)-N,N'-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine;tetrahydrochloridePG-11047 tetrahydrochlorideSCHEMBL427906orb2565548CHEMBL4296681HY-16394CS-0006318
Datenbank-Bezeichner
- CAS
206991-64-2- PubChem CID
- 9822383
- ChEMBL
CHEMBL142464、CHEMBL4296681- UNII
- HU43305R7O
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 48,1 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 14
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 153
Physikochemische Eigenschaften
- Aggregatzustand
- Solid
- Farbe
- Off-white to light yellow
Chemie und Industrie
Pharmakologische Informationen
Pharmacodynamics
CGC-11047 is a polyamine analog with anti-proliferative properties. Polyamines are cell components considered essential for cell proliferation and differentiation. They are believed to work by displacing polyamines from their natural binding sites and preventing cell replication. CGC-11047 has been very well-tolerated in Phase I clinical trials and has demonstrated promising activity in patients with advanced disease.
Mechanism of ActionThe mechanism of action of CGC-11047 is unknown but it is believed to block the growth of cancer cells by blocking the production of new DNA in the cancer cells.
Anbieter5 Anbieter
United Life Science020-82099279 18988968278 · [email protected]
斯派螺（武汉）药物研发有限公司[email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
苏州美石生物科技有限公司1173954148q · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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