Edaglitazone

HCID 9825701CAS 213411-83-7

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Grundinformationen

Standard-SMILES: Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC2SC(=O)NC2=O)c2sccc12
InChIKey: HAAXAFNSRADSMK-UHFFFAOYSA-N
Summenformel: C24H20N2O4S2
Durchschnittliche Molmasse: 464,6 g/mol
Monoisotopische Masse: 464,08644947

Namen und Bezeichner

Bevorzugter Name: Edaglitazone
IUPAC: 5-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dione
Englischer Name: 5-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)methyl)thiazolidine-2,4-dione
Summenformel: C24H20N2O4S2
Molmasse: 464.5566

Namen und Synonyme

Edaglitazone213411-83-7Edaglitazona8GKF7V499BBM-131258R-4835-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dioneDTXSID008702405-({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}methyl)-1,3-thiazolidine-2,4-dioneedaglitazonum5-((4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)-1-benzothiophen-7-yl)methyl)-1,3-thiazolidine-2,4-dioneRefChem:590569

Weitere Namen anzeigen

RO-2052349-602RO-2052349-0005-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione2,4-Thiazolidinedione, 5-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-

DTXCID908180155-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)methyl)thiazolidine-2,4-dioneEdaglitazone [INN]Edaglitazone, (+)-Edaglitazone, (-)-QP6GWW0LZD59LQZ96XUUBM 131258

Datenbank-Bezeichner

CAS: 213411-83-7、892128-35-7、892128-36-8
PubChem CID: 9825701
DTXSID: DTXSID00870240
ChEMBL: CHEMBL3990804
UNII: 59LQZ96XUU、8GKF7V499B、QP6GWW0LZD
Nikkaji: J1.244.260B

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 5,5
Polarare Oberfläche (TPSA): 135 Å²
H-Brücken-Donoren: 1
H-Brücken-Akzeptoren: 7
Frei drehbare Bindungen: 7
Schwere Atome: 32
Formalladung: 0
Komplexität: 689

Physikochemische Eigenschaften

Dichte: 1.374 · 1.374
storage temp.: -20 °C · Store at -20°C
Löslichkeit: 30 mg/ml · DMSO: 30 mg/ml
Aggregatzustand: A crystalline solid
Farbe: White to off-white

Chemie und Industrie

Anwendungen · 2 Einträge

BeschreibungEdaglitazone is an agonist of peroxisome proliferator-activated receptor γ (PPARγ). It activates PPARγ in a reporter assay using CV-1 cells expressing murine PPARγ2 when used at concentrations ranging from 0.1 to 1 μM. Edaglitazone (1, 5, and 25 μM) increases [3H]2-deoxyglucose transport in the presence and absence of insulin and increases glycogen synthesis in the presence of insulin in soleus muscle strips isolated from obese rats.

VerwendenTreatment of Type 2 diabetes.