Arformoterol Tartrate
Grundinformationen
- CAS
200815-49-2- Standard-SMILES
COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1.O=C(O)[C@H](O)[C@@H](O)C(=O)O- InChIKey
FCSXYHUNDAXDRH-OKMNHOJOSA-N- Summenformel
- C23H30N2O10
- Durchschnittliche Molmasse
- 494,5 g/mol
- Monoisotopische Masse
- 494,19004516
Überblick
Arformoterol Tartrate is the tartrate salt of arformoterol, the (R,R)-enantiomer of formoterol and a long-acting beta-2 adrenergic agonist with bronchodilator activity. Arformoterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle and lead to an inhibition of release of inflammatory mediators from mast cells. This may eventually lead to an improvement of airway function.
Namen und Bezeichner
- Bevorzugter Name
- Arformoterol Tartrate
- IUPAC
- (2R,3R)-2,3-dihydroxybutanedioic acid;N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide
- Englischer Name
- Arformoterol tartrate
- Summenformel
- C19H24N2O4.C4H6O6
- Molmasse
- 494.49
Namen und Synonyme
Arformoterol tartrate200815-49-2Brovana(R,R)-Arformoterol tartrateUNII-5P8VJ2I2355P8VJ2I235DTXSID80173903(-)-N-(2-Hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide hydrogen (2R,3R)-2,3-dihydroxybutanedioate (salt)Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt)ARFORMOTEROL TARTRATE (MART.)ARFORMOTEROL TARTRATE [MART.]Formoterol r,r-form l-tartrate
Weitere Namen anzeigen
200-589-5Aphmote tartrateAforterol tartrateR,R-Form L-tartrateAfromoterol tartrateArformoterol L-tartrate(R,R)-Formoterol tartrate(R,R)-ForMoterol-L-(+)-TartrateFormoterol Impurity 23 Tartrate
RefChem:56496Arformoterol Tartrate InhalationDTXCID6096394Arformoterol Tartrate Inhalation SolutionFormamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)Arformoterol Tartrate [USAN](2R,3R)-2,3-dihydroxybutanedioic acid;N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamideArformoterol tartrate (USAN)
Datenbank-Bezeichner
- CAS
200815-49-2- PubChem CID
- 9827062
- DTXSID
DTXSID80173903- ChEMBL
CHEMBL1951071- UNII
- 5P8VJ2I235
- EC Number
- 696-617-3
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 206 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 11
- Schwere Atome
- 35
- Formalladung
- 0
- Komplexität
- 521
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 184 ° · 184°
- storage temp.
- Refrigerator, Under Inert Atmosphere
- Löslichkeit
- DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Brown
- InChIKey
- FCSXYHUNDAXDRH-LFJODZMVNA-N
- SMILES
- C1(NC=O)=C(C=CC([C@@H](O)CN[C@H](C)CC2C=CC(=CC=2)OC)=C1)O.[C@@H]([C@H](C(O)=O)O)(C(O)=O)O |&1:8,12,25,26,r|
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P233, P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P320, P321, P330, P332+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- Alarmwort
- Achtung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
ARFORMOTEROL TARTRATE
Adrenergic beta2-Agonists [MoA]; beta2-Adrenergic Agonist [EPC]
ARFORMOTEROL TARTRATE INHALATION
beta2-Adrenergic Agonist [EPC]; Adrenergic beta2-Agonists [MoA]
ARFORMOTEROL TARTRATE INHALATION SOLUTION
beta2-Adrenergic Agonist [EPC]; Adrenergic beta2-Agonists [MoA]
Anwendungen
BeschreibungSepracor’s Brovana®, a nebulized long acting bronchodilator, was launched in the U.S. in April 2007. The β2- adrenoceptor agonist is indicated for the twice-daily, longtermmaintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema. It is the first long-acting nebulized bronchodilator approved by the FDA for this indication.
VerwendenAnti-asthmatic and bronchodilator.
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