Flonicamid
Aria · Flonicamid [iso] · flonicamid、flunicotamid · flonicamid 96% 158062-67-0 · N-(cyanoMethyl)-4-(trifluoroMethyl)nicotinaMide · N-(cyanomethyl)-4-(trifluoromethyl)pyridine-3-carboxamide · 3-Pyridinecarboxamide, N-(cyanomethyl)-4-(trifluoromethyl)- · F 1785
Identifikatoren & physikalische Daten
| CAS No. | 158062-67-0 |
|---|---|
| Summenformel | C9H6F3N3O |
| Durchschnittliche Molmasse | 229,161 g/mol |
| Monoisotopische Masse | 229,04629647 g/mol |
| SMILES | N#CCNC(=O)c1cnccc1C(F)(F)F |
| InChIKey | RLQJEEJISHYWON-UHFFFAOYSA-N |
| PubChem CID | 9834513 |
| ChEMBL | CHEMBL1882892 |
| ChEBI | CHEBI:39291 |
| EC No. | 605-127-0 |
| DTXSID | DTXSID8034611 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 157.5° |
|---|---|
| Siedepunkt | 406.6±45.0 °C(Predicted) |
| Dichte | 1.377±0.06 g/cm3(Predicted) |
| Lagerbedingungen | -20°C Freezer |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly), Ethanol (Slightly, Heated) |
| pKa (Säurekonstante) | 10.99±0.46(Predicted) |
| Aggregatzustand | Solid |
| Farbe | Light Beige to Beige |
| Henry-Konstante | 2.4×107 mol/(m3Pa) at 25℃, HSDB (2015) |
| Hauptanwendungen | agricultureenvironmental |
| InChI | InChI=1S/C9H6F3N3O/c10-9(11,12)7-1-3-14-5-6(7)8(16)15-4-2-13/h1,3,5H,4H2,(H,15,16) |
| InChIKey | RLQJEEJISHYWON-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C(F)(F)F)=C1C(NCC#N)=O |
| LogP (Verteilungskoeffizient) | 0.840 (est) |
| EPA chemische Informationen | Flonicamid (158062-67-0) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 2 |
|---|---|
| Zollcode | 29333990 |
| R-Sätze (R) | 22 |
| Toxizität | LD50 in male, female rats (mg/kg): 884, 1768 orallyin rats (mg/kg): >5000 dermallyin rats (mg/m3): >4900 by inhalationLC50 in carp, rainbow trout (mg/l): >100, >91.9 (Morita) |
| Gefahrensymbole | Xn |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 158062-67-0(Hazardous Substances Data) |
| Gefahrenklasse | Acute Tox. 4 Oral |
Anwendungen & Verwendung
Beschreibung
Flonicamid is a pyridinecarboxamide insecticide. It inhibits the brown planthopper (N. lugens) inward-rectifying potassium channel Kir1 (IC50 = 0.64 μM). Flonicamid (100 μg/ml) inhibits aphid (M. persicae) salivation and sap ingestion during feeding on Japanese radish leaves. It induces toxicity in the aphid species A. gossypii, R. padi, S. graminum, and L. erysimi (LC50s = 0.64, 0.74, 0.78, and 2.01 μg/ml, respectively) and rats (LD50 = ≥844 mg/kg). Formulations containing flonicamid have been used for the control of pest insects in agriculture.
Verwenden
Flonicamid is an novel insecticide with rapid inhibitory effect against aphid feeding.