Trestolone
Grundinformationen
- CAS
3764-87-2- Standard-SMILES
C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]21- InChIKey
YSGQGNQWBLYHPE-CFUSNLFHSA-N- Summenformel
- C19H28O2
- Durchschnittliche Molmasse
- 288,4 g/mol
- Monoisotopische Masse
- 288,20893013
Überblick
Trestolone (7α-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces a state of temporary infertility.
Namen und Bezeichner
- Bevorzugter Name
- Trestolone
- IUPAC
- (7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
- Englischer Name
- Trestolone
- Summenformel
- C19H28O2
- Molmasse
- 288.42
Namen und Synonyme
TrestoloneMENT3764-87-27alpha-Methyl-19-nortestosterone7alpha-Methylnandrolone19-Nor-methyltestosterone17beta-Hydroxy-7alpha-methylestr-4-en-3-one19-Nor-7alpha-methyltestosteroneMENTR7alpha-Methyl-3-oxo-4-estren-17beta-ol17beta-Hydroxy-7alpha-methylestr-4-enoneDTXSID20863270
Weitere Namen anzeigen
Qulong7α-Methyl-19-NTSong holds dragonMythyl testosterone7α-Methylnandrolone7α-Methyl-19-nortestosterone19-nor-7a-methyltestosterone(7R)-17-Hydroxy-7,13-diMethyl-
7alpha-Methyl-17beta-hydroxy-4-estren-3-one17-hydroxy-7-methyl-4-estren-3-oneRU 2733340P3287I94HMEORU-27333MENT steroidNSC-142229
Datenbank-Bezeichner
- CAS
3764-87-2- PubChem CID
- 9838899
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,9
- Polarare Oberfläche (TPSA)
- 37,3 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 494
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
Endocrine DisruptorsPotential endocrine disrupting compound
Physikochemische Eigenschaften
- Schmelzpunkt
- 145 · 145-146 °C
- Siedepunkt
- 375.48 °C · 375.48°C (rough estimate)
- Dichte
- 0.9447 · 0.9447 (rough estimate)
- Brechungsindex
- 1.622 · 1.6220 (estimate)
- storage temp.
- -20 °C · Store at -20°C
- Aggregatzustand
- Solid
- pka
- 15.06 · 15.06±0.60(Predicted)
- Farbe
- White to off-white
- Wasserlöslichkeit
- 92 mg/L · 92mg/L(37 ºC)
- InChI
- InChI=1/C19H28O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h10-11,14-18,21H,3-9H2,1-2H3/t11-,14+,15-,16+,17+,18-,19+/s3
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P263, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 24 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- Alarmwort
- Achtung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H315
Chemie und Industrie
Pharmakologische Informationen
Mechanism of Action
Trestolone is a potent inhibitor of the release of the luteinizing hormone (LH) and follicle stimulating hormone (FSH). As spermatogenesis requires both testosterone and FSH, it is impaired by the reduction in FSH caused by trestolone as well as the reduction in LH, and subsequent reduction in testosterone.
MeSH Pharmacological ClassificationPostcoital contraceptives which owe their effectiveness to hormonal preparations.
Anwendungen
BeschreibungTrestolone, also known as 7α-methyl-19-nortestosterone (MENT), is an experimental androgen/anabolic steroid (AAS) and progestogen medication which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low testosterone levels in men but has never been marketed for medical use.
VerwendenTrestolone is a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of termporary infertility.
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