Trifluoressigsäure-anhydrid
Trifluoroacetic anhydride
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Grundinformationen
- CAS
407-25-0- Standard-SMILES
O=C(OC(=O)C(F)(F)F)C(F)(F)F- InChIKey
QAEDZJGFFMLHHQ-UHFFFAOYSA-N- Summenformel
- C4F6O3
- Durchschnittliche Molmasse
- 210,03 g/mol
- Monoisotopische Masse
- 209,97516318
Namen und Bezeichner
- Bevorzugter Name
- Trifluoroacetic anhydride
- IUPAC
- (2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate
- Lokaler Name
- Trifluoressigsäure-anhydrid
- Englischer Name
- Trifluoroacetic anhydride
- Summenformel
- C4F6O3
- Molmasse
- 210.03
Namen und Synonyme
TRIFLUOROACETIC ANHYDRIDE407-25-0Trifluoroacetic acid anhydrideBis(trifluoroacetic) anhydridePerfluoroacetic anhydrideTrifluoroacetyl anhydrideHexafluoroacetic anhydrideAnhydrid kyseliny trifluoroctove5ENA87IZHTNSC-96965DTXSID90861920RefChem:899576
Weitere Namen anzeigen
trifluoroaceticTRIFLUORACETIC ANHYDRIDETIFLUOROACETIC ANHYDRIDETrifluoroacetic anhyTrifluoroacetic anhydride 10g [407-25-0]uoroacetic anhydridetrimethylamine (TMA)
DTXCID90810771206-982-9TFAA2,2,2-trifluoroacetic anhydrideAcetic acid, trifluoro-, anhydridetrifluoro acetic anhydride(2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate2,2,2-trifluoroacetyl 2,2,2-trifluoroacetate
Datenbank-Bezeichner
- CAS
407-25-0- PubChem CID
- 9845
- DTXSID
DTXSID90861920- UNII
- 5ENA87IZHT
- EC Number
- 206-982-9
- Nikkaji
- J5.723A
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 2,1
- Polarare Oberfläche (TPSA)
- 43,4 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 13
- Formalladung
- 0
- Komplexität
- 201
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Classes -> Acid Anhydrides, Other
PFAS
PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008
PFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds
SpringerMaterials PropertiesSchoenflies notation
Density1.49 @25 °C
Boiling Point39.5 °C @760 [mm Hg]
Vapor Pressure41.2 [mmHg]
Physical Description
Liquid
Colorless liquid; [MSDSonline]
Physikochemische Eigenschaften
- Schmelzpunkt
- -65 °C · -65 °C (lit.)
- Siedepunkt
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
P203, P260, P261, P264, P264+P265, P271, P273, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P321, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 114 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Acetic acid, trifluoro-, anhydride
Acetic acid, 2,2,2-trifluoro-, 1,1'-anhydride is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2,2,2-trifluoro-, 1,1'-anhydride are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 29-04-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/10848
Trifluoroacetic anhydride: HSNO Approval: HSR004742 Approved with controls
Hazards SummaryCorrosive to skin; [eChemPortal: ERMA] Reacts with water; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]
Hazard Classes and CategoriesSkin Corr. 1A (100%)
Sicherheit und Schutzausrüstung
Protective Action Criteria (PAC)
Chemie und Industrie
Verwendung und Herstellung
U.S. Production2023: <50,000 lb
Industry UsesIntermediate
General Manufacturing Information
Miscellaneous Manufacturing
Acetic acid, 2,2,2-trifluoro-, 1,1'-anhydride: ACTIVE
Anwendungen
VerwendenTrifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Darstellung
synthetischeTrifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
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