SR 13668
Grundinformationen
- CAS
637774-61-9- Standard-SMILES
CCOC(=O)c1ccc2[nH]c3c(OC)c4[nH]c5ccc(C(=O)OCC)cc5c4cc3c2c1- InChIKey
BMTPVPNVQOYGAP-UHFFFAOYSA-N- Summenformel
- C25H22N2O5
- Durchschnittliche Molmasse
- 430,5 g/mol
- Monoisotopische Masse
- 430,15287181
Überblick
Akt Inhibitor SR13668 is an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Namen und Bezeichner
- Bevorzugter Name
- SR 13668
- IUPAC
- diethyl 6-methoxy-5,7-dihydroindolo[2,3-b]carbazole-2,10-dicarboxylate
- Englischer Name
- SR13668
- Summenformel
- C25H22N2O5
- Molmasse
- 430.45
Namen und Synonyme
SR13668637774-61-9SR-13668SR 136682P8KGO7903RefChem:185175DTXCID40135709DTXSID40213218diethyl 6-methoxy-5,7-dihydroindolo[2,3-b]carbazole-2,10-dicarboxylateUNII-2P8KGO7903BMTPVPNVQOYGAP-UHFFFAOYSA-NCHEMBL245030
Weitere Namen anzeigen
LS-190469LS-190469Indolo[2,3-b]carbazole-2,10-dicarboxylic acid, 5,7-dihydro-6-methoxy-, 2,10-diethyl ester
orb2646081SCHEMBL1071997SCHEMBL29381258SCHEMBL30173443MAB77461SB17251HY-16469DB-202406
Datenbank-Bezeichner
- CAS
637774-61-9- PubChem CID
- 9845566
- ChEMBL
CHEMBL245030- UNII
- 2P8KGO7903
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 5,3
- Polarare Oberfläche (TPSA)
- 93,4 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 660
Physikochemische Eigenschaften
- Siedepunkt
- 688.9 · 688.9±50.0 °C(Predicted)
- Dichte
- 1.365 · 1.365±0.06 g/cm3(Predicted)
- pka
- 16.18 · 16.18±0.30(Predicted)
Chemie und Industrie
Anbieter4 Anbieter
Wuhan NCE Biomedical Co.,Ltd.4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
斯派螺（武汉）药物研发有限公司[email protected]
苏州美石生物科技有限公司1173954148q · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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