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Grundinformationen
- CAS
1811-28-5- Standard-SMILES
Nc1ccc2cc3ccc(N)cc3nc2c1.Nc1ccc2cc3ccc(N)cc3nc2c1.O=S(=O)(O)O- InChIKey
YADYXCVYLIKQJX-UHFFFAOYSA-N- Summenformel
- C26H24N6O4S
- Durchschnittliche Molmasse
- 516,583 g/mol
- Monoisotopische Masse
- 516,15797425
Namen und Bezeichner
- Bevorzugter Name
- Proflavin hemisulfate
- IUPAC
- Sulfuric acid--acridine-3,6-diamine (1/2)
- Lokaler Name
- Proflavinhemisulfat
- Englischer Name
- Proflavine hemisulfate
- Summenformel
- C13H13N3O4S
- Molmasse
- 307.32
Namen und Synonyme
PROFLAVINE HEMISULPHATEPROFLAVINE HEMISULFATE SALT3,6-DIAMINOACRIDINE HEMISULPHATEproflavine hemisulfate salt hydrate3,6-DIAMINOACRIDINIUM MONOHYDROGEN SULFATEPROFLAVINE SULFATEPROFLAVINE HEMISULFATEProflavin hemisulphatePROFLAVINE HEMISULFATEbis(acridine-3,6-diamine)
Datenbank-Bezeichner
- CAS
1811-28-5- PubChem CID
- 9849425
- DTXSID
DTXSID4043777- ChEMBL
CHEMBL465704- ChEBI
CHEBI:233302- UNII
- 27V8M747VB
- EC Number
- 217-320-3
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- DMSO (Slightly, Heated), Water (Slightly, Heated)
- Aggregatzustand
- powder
- Farbe
- Orange to Amber to Dark red
- PH
- pH (1g/l, 25℃) : 4.0～8.0
- Wasserlöslichkeit
- 2 O: · H2O: 10mg/mL
- BRN
- 3921806 · 3921806
- Stabilität
- Hygroscopic
- Major Application
- diagnostic assay manufacturinghematologyhistology
- InChI
- 1S/2C13H11N3.H2O4S.H2O/c2*14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4;/h2*1-7H,14-15H2;(H2,1,2,3,4);1H2
- InChIKey
- DTRLDKDFCPUGCA-UHFFFAOYSA-N
- SMILES
- [H]O[H].OS(O)(=O)=O.Nc1ccc2cc3ccc(N)cc3nc2c1.Nc4ccc5cc6ccc(N)cc6nc5c4
- EPA chemische Informationen
- 3 · 3,6-Acridinediamine, sulfate (2:1) (1811-28-5)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- F
- 3-8-10-23
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 2918.19.9000
- RTECS-Nr.
- AR9065100
- risk_code
- 36/37/38
- Toxizität
- mouse,LD50,subcutaneous,200mg/kg (200mg/kg),Quarterly Journal of Pharmacy & Pharmacology. Vol. 10, Pg. 649, 1937.
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungProflavine Hemisulfate, the hemisulfate form of proflavin, is an acridine-derived fluorescent contrast agent and disinfectant used for cell imaging and antiseptic purposes. Following topical application, proflavin diffuses into cells and intercalates into DNA, leading to its accumulation in and staining of the nucleus. This allows visualization of the nucleus during fluorescence imaging. Such capability enables nuclear morphometry and facilitates the identification of cancer cells. Additionally, proflavin sulfate exerts antimicrobial effects through binding to bacterial DNA, which disrupts DNA synthesis and inhibits bacterial cell growth.
VerwendenProflavine Hemisulfate is used in preparation of Adenine and Adenine nucleotides via photochemical demethylation of methyladenines.
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