NPS-2143 hydrochloride
Grundinformationen
- CAS
324523-20-8- Standard-SMILES
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N.Cl- InChIKey
ZEBNDUQLNGYBNL-VEIFNGETSA-N- Summenformel
- C24H26Cl2N2O2
- Durchschnittliche Molmasse
- 445,4 g/mol
- Monoisotopische Masse
- 444,1371335
Namen und Bezeichner
- Bevorzugter Name
- NPS-2143 hydrochloride
- IUPAC
- 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride
- Englischer Name
- 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
- Summenformel
- C24H26Cl2N2O2
- Molmasse
- 445.38
Namen und Synonyme
324523-20-8NPS-2143 hydrochlorideSB-262470 hydrochlorideU48SZ6EBB3Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)-, hydrochloride (1:1)Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)-, monohydrochlorideRefChem:202326NPS 2143 hydrochlorideNPS-2143 HCLNPS-2143 (hydrochloride)(R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochlorideCHEMBL2112075
Weitere Namen anzeigen
2NPS 2143NPS-2143 (Mono HCl)NPS2143NPS 2143 HCLSB-262470-A hydrochlorideNPS2143 hydrochloride, >=98%NPS-2143/SB-262470A hydrochloride)NPS-2143 hydrochloride (SB-262470A)NPS-2143 hydrochloride, 10 mM in DMSONPS 2143 hydrochloride, Ca2+-sensing receptor antagonist
2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile hydrochlorideC24H26Cl2N2O2NPS-2143hydrochlorideUNII-U48SZ6EBB3EX-A017Aorb1302409SCHEMBL29901576
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 65,3 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 8
- Schwere Atome
- 30
- Formalladung
- 0
- Komplexität
- 560
Physikochemische Eigenschaften
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 10 mg/mL · DMSO: >10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
- InChIKey
- ZEBNDUQLNGYBNL-VEIFNGETSA-N
- SMILES
- Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 20/21/22-50/53
- hazard_code
- Xn,N
- safety_code
- 36/37-60-61
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1
Chemie und Industrie
Anwendungen
BeschreibungCalcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM). It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously. Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.
VerwendenNPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.
Anbieter42 Anbieter
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Aladdin Scientific[email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
湖北魏氏化学试剂股份有限公司027-59102966 18717199209 · [email protected]
InvivoChem中国13549236410 · [email protected]
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