Ki-20227
Ki20227 · CS-1094 · Ki20227 ，S7688 · KI 20227 · Ki20227, 10 mM in DMSO · KI-20227 · N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea · 1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-2-methoxyphenyl)-3-(1-(thiazol-2-yl)ethyl)urea
Identifikatoren & physikalische Daten
| CAS No. | 623142-96-1 |
|---|---|
| Summenformel | C24H24N4O5S |
| Durchschnittliche Molmasse | 480,5 g/mol |
| Monoisotopische Masse | 480,14674105 g/mol |
| SMILES | COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 |
| InChIKey | SHPFDGWALWEPGS-UHFFFAOYSA-N |
| PubChem CID | 9869779 |
| ChEMBL | CHEMBL1908396 |
| DTXSID | DTXSID80432108 |
Chemische & physikalische Eigenschaften
| XLogP | 3,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 132 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 8 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 34 |
| Formalladung | 0 |
| Komplexität | 661 |
| Siedepunkt | 621.8±55.0 °C(Predicted) |
| Dichte | 1.327 |
| Lagerbedingungen | Sealed in dry,Store in freezer, under -20°C |
| Löslichkeit | ≥48.1 mg/mL in DMSOinsoluble in H2O≥8.6 mg/mL in EtOH with gentle warming and ultrasonic |
| Aggregatzustand | Brown powder. |
| pKa (Säurekonstante) | 12.03±0.46(Predicted) |
| Farbe | Off-white to pink |
Anwendungen & Verwendung
Beschreibung
Ki20227 is an inhibitor of macrophage colony stimulating factor 1 (CSF1) receptor tyrosine kinase (c-Fms; IC50 = 2 nM). It inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells and reduces CSF1-dependent growth of M-NFS-60 cells (IC50 = 14 nM). Ki20227 suppresses development of TRAP-positive osteoclast-like cells from murine bone marrow (IC50 = 40 nM) and decreases the number and area of osteolytic lesions on femurs and tibiae in a murine A375 subcutaneous xenograft model. Ki20227 also reduces TNF-α infiltration and osteolytic bone destruction in a collagen-induced arthritis (CIA) mouse model.
Verwenden
Ki 20227 is a c-fms tyrosine kinase inhibitor, which suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.