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Methylfluorsulfat
magicmethyl · methylfluorosulfate · methylfluosulfonate · methyl fluorosulphate · Methyl Sulfofluoridate · Methyl fluorosulfonate · METHYL FLUOROSULPHONATE · fluorosulfonyloxymethane
Identifikatoren & physikalische Daten
| CAS No. | 421-20-5 |
|---|---|
| Summenformel | CH3FO3S |
| Durchschnittliche Molmasse | 114,1 g/mol |
| Monoisotopische Masse | 113,97869318 g/mol |
| SMILES | COS(=O)(=O)F |
| InChIKey | MBXNQZHITVCSLJ-UHFFFAOYSA-N |
| PubChem CID | 9870 |
| EC No. | 207-004-3 |
| DTXSID | DTXSID8073180 |
| Lokaler Name | Methylfluorsulfat |
Chemische & physikalische Eigenschaften
| XLogP | 0,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 51,8 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 6 |
| Formalladung | 0 |
| Komplexität | 107 |
| Stoffklassen | Other Classes -> Other Organic Compounds |
| SpringerMaterials Properties | Schoenflies notation |
| Dichte | 1.427 @ 16°C1.45 |
| Siedepunkt | 92 °C @760 [mm Hg]93 °C |
| Physical Description | Colorless liquid with an ethereal odor[Hawley] Cloudy colorless or yellow liquid[MSDSonline] |
| Schmelzpunkt | -95° |
| Brechungsindex | nD20 1.3326 |
| Flammpunkt | 10℃ |
| Aggregatzustand | liquid |
| Merck | 6075 |
| CAS Datenbank | 421-20-5(CAS DataBase Reference) |
| EPA chemische Informationen | Fluorosulfuric acid, methyl ester (421-20-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Gefahrenübersicht | Extremely toxicMay cause pulmonary edema[Merck Index] Reacts with moisture producing corrosive vaporA strong tissue irritant[Hawley] Evolves hydrofluoric and sulfuric acid on contact with water[ChemIDplus] Corrosive to skin of rabbitsMay cause pulmonary edema and corneal damageEmergency treatment: see Hydrogen fluoride. [HSDB] A mutagenCauses lacrimation and dyspnea in lethal-dose inhalation studies of rats[RTECS] An irritantMay cause serious eye injury[MSDSonline] |
| Highly Hazardous Substance | Chemical: Methyl Fluorosulfate |
| Hazard Classes and Categories | Flam. Liq. 2 (100%) |
| Preventive Measures | METHYL FLUOROSULFATE SHOULD BE ASSUMED TO BE EXTREMELY TOXIC & SHOULD ALWAYS BE HANDLED WITH SUITABLE PRECAUTIONS. |
| Protective Action Criteria (PAC) | 0.0021 [ppm]0.023 [ppm]0.14 [ppm] |
| Personal Protective Equipment (PPE) | THIS COMPD IS A POTENTIAL CARCINOGEN. IT SHOULD BE HANDLED WITH GLOVES & WITH EFFICIENT FUME-CUPBOARD PROTECTION. |
| Unerwünschte Wirkungen | Dermatotoxin - Skin burns. |
| Human Toxicity Excerpts | THE POTENTIAL HAZARDS INCL PULMONARY EDEMA & CORNEAL DAMAGE ARE REITERATED.INHALATION OF A MINUTE QUANTITY PROVED FATAL TO A 25-YR-OLD WHO SPILLED A FEW MILLILITERS OF FLUID CONTAINING METHYLFLUOROSULFONATE ON HIS CLOTHING.EVALUATED IN 2 IN VITRO ASSAYS, SALMONELLA REVERSE MUTATION ASSAY OF AMES & CELL TRANSFORMATION ASSAY OF STYLES. FINDINGS WERE CONSISTENT WITH THIS MATERIAL BEING A POSSIBLE CARCINOGEN.MARKEDLY TOXIC BY ALL ROUTES STUDIED (ORAL, INHALATION, OCULAR & DERMAL) PARTICULARLY BY INHALATION ROUTE. |
| Non-Human Toxicity Excerpts | EYE IRRITATION STUDY IN RABBITS SHOWED THAT IT WAS SEVERELY IRRITATING & CAPABLE OF PRODUCING TOXIC SIGNS & DEATH BY OCULAR ROUTE. DERMAL IRRITATION STUDY IN RABBITS SHOWED THAT IT WAS NOT ONLY CORROSIVE TO SKIN BUT ALSO CAPABLE OF CAUSING DEATH BY THIS ROUTE. |
| Antidote and Emergency Treatment | REMOVE CONTAMINATED CLOTHING IMMEDIATELY & DISPOSE OF WITH GREAT CARE. PROTECT PERSONNEL PROVIDING CARE FROM CONTAMINATION.IMMEDIATE ADMIN OF CORTICOSTEROIDS SHOULD BE CONSIDERED IF THIS AGENT IS THOUGHT TO HAVE BEEN INHALED. CONTINUOUS CLOSE OBSERVATION DURING FIRST 24 HR IS NECESSARY. |
| Toxicity Data | LC50 (rat) = 5 ppm/1h |
| UN-Transportnummer | 3265 |
| RTECS-Nr. | LP0720000 |
| R-Sätze (R) | 34 |
| Toxizität | LD50 orally in mice: <112 mg/kgLC50 1 hr for rats: 5-6 ppm (Hite) |
| Gefahrensymbole | C |
| hazard_note | Corrosive |
| Sicherheitshinweise (S) | 26-36/37/39 |
| Gefahrstoffdaten | 421-20-5(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
In organic synthesis as methylating agent.