Prucalopride Succinate
Grundinformationen
- CAS
179474-85-2- Standard-SMILES
COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1.O=C(O)CCC(=O)O- InChIKey
QZRSNVSQLGRAID-UHFFFAOYSA-N- Summenformel
- C22H32ClN3O7
- Durchschnittliche Molmasse
- 486 g/mol
- Monoisotopische Masse
- 485,1928781
Überblick
Prucalopride Succinate is the succinate salt form of prucalopride, an orally bioavailable dihydro-benzofuran-carboxamide and selective serotonin (5-HT4) receptor agonist, with gastrointestinal (GI) prokinetic activity. Upon oral administration, prucalopride specifically targets, binds to and stimulates the 5-HT4 receptor. This alters colonic motility patterns and stimulates colonic mass movements. This may normalize bowel movements and may relief chronic constipation. In addition, by increasing esophageal and gastric motility, prucalopride may also provide relief for aspiration-associated symptoms.
Namen und Bezeichner
- Bevorzugter Name
- Prucalopride Succinate
- IUPAC
- 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid
- Englischer Name
- Prucalopride Succinate
- Summenformel
- C22H32ClN3O7
- Molmasse
- 485.96
Namen und Synonyme
Prucalopride succinate179474-85-2R-108512Prucalopride (as succinate)Motegrity4V2G75E1CKDTXSID701027749RefChem:57531DTXCID801513325ResolorPrucalopride SuccinatPrucalopride (succinate)
Weitere Namen anzeigen
Resolor SuccinatePucapride SuccinatePRUCALOPRIDE SUCCITEPrucalopride ImpurityPriucapride succinatePulucapride Succinate
BUTANEDIOIC ACID 4-AMINO-5-CHLORO-2,3-DIHYDRO-N-[1-(3-METHOXYPROPYL)-4-PIPERIDINYL]-7-BENZOFURANCARBOXAMIDEMFCD00948731Prucalopride succinate [USAN]4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinateAKOS0159947414-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acidKS-1283PRUCALOPRIDE SUCCINATE [ORANGE BOOK]
Datenbank-Bezeichner
- CAS
179474-85-2- PubChem CID
- 9870009
- DTXSID
DTXSID701027749
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 151 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 33
- Formalladung
- 0
- Komplexität
- 538
Experimentelle und physikochemische Eigenschaften
Human Drugs
Breastfeeding; Lactation; Gastrointestinal Agents; Laxatives; Serotonin 5-HT4 Receptor Agonists
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 196 °C · >196°C (dec.)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Brown
- InChIKey
- QZRSNVSQLGRAID-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCC(O)=O.O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (87.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (87.5%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Prucalopride succinate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
PRUCALOPRIDE SUCCINATE
Serotonin 4 Receptor Agonists [MoA]; Serotonin-4 Receptor Agonist [EPC]
MeSH Pharmacological Classification
Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS.
Anwendungen
VerwendenPrucalopride Succinate is the succinate form of prucalopride. It is a selective 5-HT4 receptor agonist used for the treatment of chronic constipation in adults for whom laxatives are not effective. It is not indicated for use in children and adolescents under 18 years of age.
Anbieter100 Anbieter
济南百隆化学有限公司[email protected] · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
湖北研科时代科技有限公司15780669880 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
芷威（上海）化学科技有限公司021-20221225 13917446399 · [email protected]
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