3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol
Grundinformationen
- CAS
371943-05-4- Standard-SMILES
Oc1cccc(-c2nc(N3CCOCC3)c3sccc3n2)c1- InChIKey
XXLAEKOWCYJOKK-UHFFFAOYSA-N- Summenformel
- C16H15N3O2S
- Durchschnittliche Molmasse
- 313,4 g/mol
- Monoisotopische Masse
- 313,0884979
Überblick
PI3-Kinase alpha Inhibitor 2 is an organic heterobicyclic compound, an organonitrogen heterocyclic compound and an organosulfur heterocyclic compound.
Namen und Bezeichner
- Bevorzugter Name
- 3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol
- IUPAC
- 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol
- Englischer Name
- PI3-Kinase α Inhibitor 2
- Summenformel
- C16H15N3O2S
- Molmasse
- 313.37
Namen und Synonyme
371943-05-4Compound 15e3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenolPI3-Kinase alpha Inhibitor 2PI3K-IN-183-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenolthienopyrimidine derivative, 13-[4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-2-yl]phenolPI3-Kinase |A Inhibitor 2PI3-Kinase inhibitor 2PI3-K alpha Inhibitor 2PI3-Kinase ? Inhibitor 2
Weitere Namen anzeigen
PI3-Kinase α Inhibitor 2Compound 15e, 98.0+ % (HPLC)PI3-Kinase .alpha. Inhibitor 2PI 3-Kinase Inhibitor 2 B-0304PI3-Kinase α Inhibitor 2 Exclusive3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]PhenolPhenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
SCHEMBL258501PI3-Kinase ?? Inhibitor 2CHEMBL510164orb1694544SCHEMBL29395747BDBM25018DTXSID50432599CHEBI:187241
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,7
- Polarare Oberfläche (TPSA)
- 86,7 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 380
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 30 mg/ml; · DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
- Aggregatzustand
- White to off-white solid.
- Farbe
- White to off-white
Chemie und Industrie
Anwendungen
BeschreibungPI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM.
Anbieter13 Anbieter
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海芮珊医药科技有限公司02150565560; 17321237488 · [email protected]
上海宏叶生物科技有限公司400-9205774 400-920-5774 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
苏州诺行贸易有限公司0512-65816829 18662214788 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
Zugehörige Reaktionen
3
Notizen zur Verbindung
Wird geladen…