Flb 457
Grundinformationen
- CAS
107188-66-9- Standard-SMILES
CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC- InChIKey
QAECXZXKVURFMR-LBPRGKRZSA-N- Summenformel
- C16H23BrN2O3
- Durchschnittliche Molmasse
- 371,27 g/mol
- Monoisotopische Masse
- 370,08921
Überblick
RN given refers to parent cpd without isomeric designation; structure given in first source
Namen und Bezeichner
- Bevorzugter Name
- Flb 457
- IUPAC
- 5-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,3-dimethoxybenzamide
- Englischer Name
- (-)-(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-benzamide
- Summenformel
- C16H23BrN2O3
- Molmasse
- 371.27
Namen und Synonyme
Flb 457Flb-457RefChem:140678107188-66-9107188-74-9Isoremoxipride5-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,3-dimethoxybenzamide(-)-(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-benzamideGH32HX9WCXCHEMBL289330(S)-5-BROMO-N-((1-ETHYLPYRROLIDIN-2-YL)METHYL)-2,3-DIMETHOXYBENZAMIDEBenzamide, 5-bromo-N-(((2S)-1-ethyl-2-pyrrolidinyl)methyl)-2,3-dimethoxy-
Weitere Namen anzeigen
FLB 457107188-74-95-Bromo-2,3-dimethoxy-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]benzamideBENZAMIDE, 5-BROMO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2,3-DIMETHOXY-BENZAMIDE, 5-BROMO-2,3-DIMETHOXY-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-, (S)-
5-BROMO-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2,3-DIMETHOXYBENZAMIDEUNII-GH32HX9WCXorb3174725SCHEMBL5477770DTXSID40432689BDBM50007522AKOS0221801965-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dimethoxy-benzamide
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,7
- Polarare Oberfläche (TPSA)
- 50,8 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 369
Physikochemische Eigenschaften
- Schmelzpunkt
- 51 · 51-53°C
- storage temp.
- -20 °C · -20°C Freezer
- Löslichkeit
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Light Yellow to Yellow
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Anwendungen
VerwendenFLB 457 is an intermediate in the synthesis of FLB 457 Hydrobromide which is a potential antipsychotic agent; antidopaminergic.
Anbieter8 Anbieter
奥夫仑医药（四川）有限公司17336178085 · [email protected]
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD+8613676922317 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
泰迩生物医药泰州有限公司052386810091 · [email protected]
江苏艾康生物医药研发有限公司025-58859352 17714375163 · [email protected]
济南睿思医药技术有限公司0531-0531-69900633 19963472814 · [email protected]
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