Pixantrone dimaleate
Daten werden ergänzt – meist innerhalb einer Minute fertig
Grundinformationen
- CAS
144675-97-8- Standard-SMILES
NCCNc1ccc(NCCN)c2c1C(=O)c1ccncc1C2=O.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O- InChIKey
SVAGFBGXEWPNJC-SPIKMXEPSA-N- Summenformel
- C25H27N5O10
- Durchschnittliche Molmasse
- 557,5 g/mol
Überblick
Pixantrone Dimaleate is the dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.
Namen und Bezeichner
- Bevorzugter Name
- Pixantrone dimaleate
- IUPAC
- 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione;bis((Z)-but-2-enedioic acid)
Namen und Synonyme
Pixantrone dimaleatePixantrone maleate144675-97-8PixuvriPixoltiBBR 2778Pixantrone (dimaleate)Pixantrone dimaleate [USAN]6,9-bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione dimaleateBBR 2778 dimaleateBBR-2778 dimaleatePixantrone dimaleate salt
Weitere Namen anzeigen
MFCD00920108P0R64C4CR9NSC-752341AS-74252BP164036Pixuvri (TN)D09654F14530
Datenbank-Bezeichner
- CAS
144675-97-8- PubChem CID
- 9937618
- ChEMBL
CHEMBL2103844- UNII
- P0R64C4CR9
- EC Number
- 680-661-5
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 272 Ų
- H-Brücken-Donoren
- 8
- H-Brücken-Akzeptoren
- 15
- Frei drehbare Bindungen
- 10
- Schwere Atome
- 40
- Formalladung
- 0
- Komplexität
- 591
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Danger
H300 (50%): Fatal if swallowed [Danger Acute toxicity, oral]
P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P308+P316, P316, P318, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 2 (50%)
Zugehörige Reaktionen
1
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