JTE-607 free base

JTE-607 free base is a secondary carboxamide resulting from the formal condensation of the carboxy group of 3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoic acid with the amino group of ethyl L-phenylalaninate. It inhibits cytokine production in human peripheral blood mononuclear cells (PBMC's) without causing immunosuppression. It has a role as a CPSF3 inhibitor, an antineoplastic agent, a prodrug, an anti-inflammatory agent and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a dichlorobenzene, an ethyl ester, a member of phenols, an aromatic ether, a N-methylpiperazine and a L-phenylalanine derivative. It is a conjugate base of a JTE-607(2+). It is a tautomer of a JTE-607 zwitterion.