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Bremelanotide

HCID 9941379
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Grundinformationen

CAS
189691-06-3
Standard-SMILES
CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O
InChIKey
FFHBJDQSGDNCIV-MFVUMRCOSA-N
Summenformel
C50H68N14O10
Durchschnittliche Molmasse
1.025,182 g/mol
Monoisotopische Masse
1.024,52428438

Namen und Bezeichner

Bevorzugter Name
Bremelanotide
IUPAC
(3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-(3-carbamimidamidopropyl)-12-[(1H-imidazol-5-yl)methyl]-3-[(1H-indol-3-yl)methyl]-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid
Englischer Name
BREMELANOTIDE
Summenformel
C50H68N14O10
Molmasse
1025.18

Namen und Synonyme

PT 141PT-141 (BREMELANOTIDE)N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine (2-7)-lactamBremelanotide,α-MSH (PT-141)MTPT-141BremerdamREMELANOTIDEBrmelanoticeBREMELANOTIDEPeptide PT-141

Datenbank-Bezeichner

CAS
189691-06-3
PubChem CID
9941379
DTXSID
DTXSID40893711
ChEMBL
CHEMBL2070241
ChEBI
CHEBI:177849
UNII
6Y24O4F92S

Eigenschaften

Physikochemische Eigenschaften

Dichte
1.43 · 1.43
Löslichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Aggregatzustand
Solid
pka
3.37 · 3.37±0.70(Predicted)
Farbe
White to Off-White
Stabilität
30 days · Un-reconstituted lyophilized powder should be stored under refrigeration per vial’s instruction. After reconstitution with bacteriostatic water, refrigerate solution and use within 30 days. If buffered solution is used, stability will improve.
InChIKey
FFHBJDQSGDNCIV-MLYCVURTNA-N

Chemie und Industrie

Anwendungen · 2 Einträge

BeschreibungBremelanotide (Vyleesi®) was approved by the FDA in June 2019 for the treatment of acquired, generalized HSDD in premenopausal women. Bremelanotide activates melanocortin receptors,but the mechanism by which it improves sexual desire is unknown. To use bremelanotide, women inject it under the skin ofthe abdomen or thigh at least 45 minutes before anticipated sexual activity.The optimal time to inject bremelanotide may vary based on the duration of benefit and side effects experienced. More than one dose of bremelanotide should not be used within 24 hours or more than eight doses per month. Common side effects include nausea, vomiting, flushing, injection site reactions, and headache. Bremelanotide should not be used in women with high blood pressure that is uncontrolled or in those with known cardiovascular disease, and it is not recommended for women at high risk for cardiovascular disease. The safety and efficacy of bremelanotide has not been studied in breast cancer survivors, and there are no recommendations regarding its use in this population.

VerwendenTreatment of sexual dysfunction (melanocortin receptor agonist).Bremelanotide is used to treat low sexual desire in women who have not gone through menopause and have not had low sexual desire in the past.bremelanotide should be used only to treat low sexual desire that occurs with any type of sexual activity, in any sexual situation, or with any sexual partner.Bremelanotide should not be used to treat low sexual desire that is caused by relationship problems, health problems, mental illness, or by using certain drugs or medications.https://www.drugs.com

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