(±)-2-Propylpiperidin

2-Propylpiperidine

HCID 9985CAS 3238-60-6

Grundinformationen

Standard-SMILES
CCCC1CCCCN1
InChIKey
NDNUANOUGZGEPO-UHFFFAOYSA-N
Summenformel
C8H17N
Durchschnittliche Molmasse
127,23 g/mol
Monoisotopische Masse
127,13609955

Namen und Bezeichner

Bevorzugter Name
2-Propylpiperidine
IUPAC
2-propylpiperidine
Lokaler Name
(±)-2-Propylpiperidin
Englischer Name
2-Propylpiperidine
Summenformel
C8H17N
Molmasse
127.23

Namen und Synonyme

2-PropylpiperidineRefChem:4832873238-60-62-N-propylpiperidinedl-Coniine(+/-)-Coniinepiperidine, 2-propyl-(S)-2-Propylpiperidine(S)-ConiineMFCD00056022DTXSID3046821CONIINE, D/L-(RG)
Weitere Namen anzeigen
CONIINE(±)-Coniinerac-coniine(+/-)CONINECONIINE, DL-2-PRIOPYLPIPERIDINE(R)-2-Propylpiperidine
10388-95-1Piperidine, 2-propyl-, (2S)-04R53ZF48T( inverted exclamation markA)-ConiineNCGC00181040-01DTXCID1026821HSDB 3474EINECS 207-282-6

Datenbank-Bezeichner

CAS
3238-60-6、458-88-8
PubChem CID
9985
DTXSID
DTXSID3046821
ChEMBL
CHEMBL21867
ChEBI
CHEBI:229941
UNII
04R53ZF48T
EC Number
221-801-3
Nikkaji
J1.077.264H

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2
Polarare Oberfläche (TPSA)
12 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
2
Schwere Atome
9

Experimentelle und physikochemische Eigenschaften

Solubility18 mg/mL
Melting Point-2 °C
Physical DescriptionLiquid
Kovats Retention Index992

Physikochemische Eigenschaften

Schmelzpunkt
-2 ℃ · -2℃
Siedepunkt
56 · 56-60 °C(Press: 13 Torr)
Dichte
0.85 g/mL · 0.85 g/mL at 25 °C(lit.)
storage temp.
2 · Sealed in dry,2-8°C
Aggregatzustand
liquid
pka
1 · pK1:11.24(+1) (25°C,μ=0.5)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H226 (97.5%): Flammable liquid and vapor [Warning Flammable liquids];H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral];H311 (97.5%): Toxic in contact with skin [Danger Acute toxicity, dermal];H331 (97.5%): Toxic if inhaled [Danger Acute toxicity, inhalation];H351 (97.5%): Suspected of causing cancer [Warning Carcinogenicity]

P203, P210, P233, P240, P241, P242, P243, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P316, P318, P321, P330, P361+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Hazard Classes and CategoriesFlam. Liq. 3 (97.5%);Acute Tox. 3 (97.5%);Acute Tox. 3 (97.5%);Acute Tox. 3 (97.5%);Carc. 2 (97.5%)

Toxikologische Informationen

Health EffectsDisruption of the peripheral nervous system; respiratory paralysis; death.
Toxicity Summary · 1 Eintrag

(S)-2-Propylpiperidine is a neurotoxin which disrupts the peripheral nervous system. It is toxic to humans and all classes of livestock; less than 0.2g is fatal to humans, with death caused by respiratory paralysis. Propylpiperidine has a nicotine-like action in first stimulating and then depressing autonomic ganglia, and a curare-like effect in paralysing the motor nerve endings to the skeletal muscles.

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Sicherheitsdaten

wgk
3
ridadr
UN 2810 6.1/PG 2
hs_code
2933399990
risk_code
23/24/25-40
Toxizität
Piperidine alkaloid obtained from poison hemlock, Conium maculatum. Alkaline, steam volatile liquid (b.p. 167_x0003_C), mousy odor. Darkens and polymerizes in air. It can be reduced at high temperature with HI to n-octane and oxidized to pyridine-1-carboxylic acid. The hydrochloride is used as an antispasmodic.
hazard_code
T

Chemie und Industrie

Pharmakologische Informationen

Cellular LocationsCytoplasm;Extracellular

Verwendung und Herstellung

Uses(S)-2-Propylpiperidine is found in black elderberry.

Anwendungen

VerwendenConiine is present in all parts of the plantpoison hemlock (Conium maculatum). It isthe first alkaloid to be synthesized and structure determined. Because of its high toxicity,its clinical application is very limited.

Anbieter35 Anbieter

广州诚创生物科技有限公司18027266590 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
北京炎礼生物科技有限公司18600731423 · [email protected]
苏州维塔力生物医药有限公司512-68242903 13916956214 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]

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