2-Bromopropane → N-(12-Hydroxydodecyl)-6-(4-isopropyl-1-piperazinyl)pyridine-3-carboxamide

HRID 1003304Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1003304
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:18]=[N:19][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:21][CH:22]=1)=[O:16].[CH:29](Br)([CH3:31])[CH3:30].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.C(Cl)(Cl)Cl>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:18]=[N:19][C:20]([N:23]2[CH2:24][CH2:25][N:26]([CH:29]([CH3:31])[CH3:30])[CH2:27][CH2:28]2)=[CH:21][CH:22]=1)=[O:16]

Komponenten

6

Edukt 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 18796424N-(12-hydroxydodecyl)-6-(1-piperazinyl)pyridine-3-carboxamide

Produkt 1

HCID 15462626N-(12-Hydroxydodecyl)-6-(4-isopropyl-1-piperazinyl)pyridine-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 0.7 g of N-(12-hydroxydodecyl)-6-(1-piperazinyl)pyridine-3-carboxamide, 0.24 g of isopropyl bromide and 0.7 g of potassium carbonate in 20 ml of dimethylformamide was stirred at 100° C. for 3 hours. The reaction solution was diluted with chloroform, washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column to afford the title compound as a crystal.

Aufarbeitung

  1. washwashed with water
  2. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure
  4. customThe residue thus obtained
  5. customwas chromatographed over a silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-fdfa2ac44cd84b5da77bd1f6e8da6666
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06046201

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