Hydrochloric Acid → 12-Iodododecylamine hydrochloride

HRID 1003314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1003314
[I:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[I:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 1879643112-(Boc-amino)-1-dodecyl iodine

Produkt 1

HCID 1879643312-Iodododecylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 0.33 g of tert-butyl N-(12-iodododecyl)carbamate in 25 ml of ethyl acetate was added 2.6 ml of hydrochloric acid and the mixture was stirred for 0.5 hour. The reaction solution was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Crystallization from ethyl acetate and hexane afforded 0.17 g of the title compound.

Aufarbeitung

  1. distillationThe reaction solution was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure
  6. customCrystallization from ethyl acetate and hexane

Quellen und Nachweise

ORD-Eintrag
ord-9d8086cb726c47e79befbdda465bcca0
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06046201

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