Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → 6-Methoxy-4,4-dimethyl-2,3,4,5-tetrahydropyridine

Reaktionsgleichung

[CH3:1][C:2]1([CH3:9])[CH2:7][CH2:6][NH:5][C:4](=[O:8])[CH2:3]1.F[B-](F)(F)F.[CH3:15][O+](C)C>>[CH3:1][C:2]1([CH3:9])[CH2:3][C:4]([O:8][CH3:15])=[N:5][CH2:6][CH2:7]1

Komponenten

Edukt 2

HCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)

HCID 122020974,4-Dimethylpiperidin-2-one

Produkt 1

HCID 184285206-Methoxy-4,4-dimethyl-2,3,4,5-tetrahydropyridine

Versuchsvorschrift

A sample of the title compound of EXAMPLE 168 (636 mg, 5 mmol) was reacted with trimethyloxonium tetrafluoroborate (890 mg, 6 mmol) by the method of EXAMPLE 26 to yield, after chromatography, 550 mg (78%) of the title material.

Aufarbeitung

customto yield

Quellen und Nachweise

ORD-Eintrag: ord-9987f852cb21474b9cc81b98d8e7172c
Quelldatensatz: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06046211

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