Ethanol → 5-(4,5-dihydrothiazol-5-yl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 1003591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1003591
C([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[C:12]1[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=1)#N.[SH:19][CH2:20][CH2:21][NH2:22].[CH2:23](O)C>>[S:19]1[CH:20]([C:3]2[CH:4]=[C:5]3[C:9](=[CH:10][CH:11]=2)[NH:8][CH:7]=[C:6]3[C:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=2)[CH2:21][N:22]=[CH:23]1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 6058CysteamineHCID 149732163-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile

Produkt 1

HCID 187971695-(4,5-dihydrothiazol-5-yl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleAusbeute 51 %

Versuchsvorschrift

A mixture of 1.0 gm (4.2 mMol) 5-cyano-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and 0.90 gm (11.7 mMol) 2-mercaptoethylamine in 20 mL ethanol was heated to reflux for 18 hours. The reaction mixture was cooled to room temperature and a colorless crystalline solid formed. The solid was isolated by filtration, washed with ethanol and dried under reduced pressure to provide 0.64 gm (51%) of the title compound.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customa colorless crystalline solid formed
  4. customThe solid was isolated by filtration
  5. washwashed with ethanol
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e52a4bc462944199835d2ce544719e0e
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06046215

Notizen zur Reaktion

Wird geladen…