p-Xylyl bromide → S-p-Methylbenzyl-L-cysteine

HRID 1003649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1003649
O.Cl.[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6].Br[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1>[OH-].[Na+].C(O)C>[CH3:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][S:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[NH2:3])=[CH:14][CH:13]=1

Komponenten

5

Edukt 2

HCID 7721p-Xylyl bromideHCID 23462L-Cysteine hydrochloride monohydrate

Produkt 1

HCID 13994756S-p-Methylbenzyl-L-cysteine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

L-Cysteine hydrochloride monohydrate (2.0 g) is dissolved in a 2 N aqueous sodium hydroxide solution (11.4 ml). To the solution is added a solution of α-bromo-p-xylene (2.3 g) in ethanol (10 ml). The mixture is stirred at room temperature for 40 minutes, and precipitating crystals are filtered off. The obtained crystals are purified by recrystallization to give the titled compound.

Aufarbeitung

  1. customprecipitating crystals
  2. filtrationare filtered off
  3. customThe obtained crystals are purified by recrystallization

Quellen und Nachweise

ORD-Eintrag
ord-2bd0214789884754b1d748c3c1b81b2a
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06046235

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