Methanol → Methyl (2-chlorophenyl)acetate

HRID 1004306

Reaktionsgleichung

Reaktionsgleichung von HRID 1004306
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 17124o-Chlorophenylacetic acid

Produkt 1

HCID 93683Methyl (2-chlorophenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidKatalysator

Versuchsvorschrift

A solution of 2-chlorophenylacetic acid (10.0 g) in methanol (100 ml) containing 1 drop of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was evaporated to half volume and partitioned between ethyl acetate (100 ml) and water (100 ml). The organic phase was dried over magnesium sulphate and evaporated to give the title compound (10.0 g) as a colourless oil.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. customThe reaction mixture was evaporated to half volume
  4. custompartitioned between ethyl acetate (100 ml) and water (100 ml)
  5. dry with materialThe organic phase was dried over magnesium sulphate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-9fca659e73f847a3a5eb5a0804ca6a53
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06048893

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