Methanol → Methyl [2-(trifluoromethyl)phenyl]acetate

HRID 1004308Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1004308
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=[O:11].[CH3:15]O>S(=O)(=O)(O)O>[F:1][C:2]([F:13])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([O:12][CH3:15])=[O:11]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 594597(2-(trifluoromethyl)phenyl)acetic acid

Produkt 1

HCID 23294844Methyl [2-(trifluoromethyl)phenyl]acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidKatalysator

Versuchsvorschrift

A solution of 2-trifluoromethylphenylacetic acid (5.0 g) in methanol (30 ml) containing 5 drops of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was concentrated, diluted with ethyl acetate (100 ml), washed with 1N sodium hydroxide (25 ml) then with brine (25 ml), dried over magnesium sulphate and evaporated to give the title compound (5.04 g) as a colourless oil.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. concentrationThe reaction mixture was concentrated
  4. additiondiluted with ethyl acetate (100 ml)
  5. washwashed with 1N sodium hydroxide (25 ml)
  6. dry with materialwith brine (25 ml), dried over magnesium sulphate
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e310ac7d8779480c96918d4b492204f8
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06048893

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