2-amino-4-phenyl-1H-pyrrole-3-carbonitrile → 5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 1004604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1004604
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][C:11](OC)=[CH:10][CH:9]=2)=[CH:6][NH:5][C:4]=1[NH:16][CH:17]=[NH:18])#[N:2].NC1NC=C(C2C=CC=CC=2)C=1C#N>C(OCC)(OCC)OCC>[C:8]1([C:7]2[C:3]3[C:1]([NH2:2])=[N:18][CH:17]=[N:16][C:4]=3[NH:5][CH:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 27668732-amino-4-phenyl-1H-pyrrole-3-carbonitrileHCID 178488786HCID 178488786, Verbindung

Produkt 1

HCID 53577645-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31214Ethyl orthoformateLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

N-[3-Cyano-4-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-formamidine: 6.0 g of 2-amino-4-phenyl-1H-pyrrole-3-carbonitrile are dissolved in 80 ml of triethyl orthoformate, and the solution is stirred for 1 hour at 140° C. The triethyl orthoformate is removed under a high vacuum and the residue is dissolved in methanol saturated with ammonia. Stirring is carried out for 24 hours at room temperature, followed by filtration. The product is recrystallised from ethanol. M.p.: 238-239° C.

Aufarbeitung

  1. customThe triethyl orthoformate is removed under a high vacuum
  2. dissolutionthe residue is dissolved in methanol saturated with ammonia
  3. stirringStirring
  4. waitis carried out for 24 hours at room temperature
  5. filtrationfollowed by filtration
  6. customThe product is recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-21eb41dcca5947c69200a28d2ddf9277
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06051577

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