2-Amino-4-(3-methoxyphenyl)-1H-pyrrole-3-carbonitrile → HCID 18792871, Verbindung

HRID 1004605Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1004605
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)=[CH:6][NH:5][C:4]=1[NH:16][CH:17]=[NH:18])#[N:2].NC1NC=C(C2C=CC=C(OC)C=2)C=1C#N>C(OCC)(OCC)OCC>[CH3:15][O:14][C:10]1[CH:9]=[C:8]([C:7]2[C:3]3[C:1]([NH2:2])=[N:18][CH:17]=[N:16][C:4]=3[NH:5][CH:6]=2)[CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 187929202-Amino-4-(3-methoxyphenyl)-1H-pyrrole-3-carbonitrileHCID 178489845HCID 178489845, Verbindung

Produkt 1

HCID 18792871HCID 18792871, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31214Ethyl orthoformateLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

N-[3-Cyano-4-(3-methoxy-phenyl)-1H-pyrrol-2-yl]formamidine: 5.30 g of 2-amino4-(3-methoxy-phenyl)-1H-pyrrole-3-carbonitrile are dissolved in 50 ml of triethyl orthoformate, and the solution is stirred for 1 hour at 140° C. The triethyl orthoformate is removed under a high vacuum and the residue is dissolved in methanol saturated with ammonia. Stirring is carried out for 20 hours at room temperature, followed by filtration. The product is recrystallised from ethanol. M.p.: 188-190° C.

Aufarbeitung

  1. customThe triethyl orthoformate is removed under a high vacuum
  2. dissolutionthe residue is dissolved in methanol saturated with ammonia
  3. stirringStirring
  4. waitis carried out for 20 hours at room temperature
  5. filtrationfollowed by filtration
  6. customThe product is recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-85c73a0a5b7743778a37065400de14ab
Quelldatensatz
uspto-grants-2000_04
Patentnummer
US06051577

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