Iodine → 5-Iodo-4-methyl-3-nitro-1,2-dihydropyridin-2-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 4-methyl-3-nitro-2-pyridone (2.00 g, 13 mmol) in acetic acid (12 mL) and concentrated sulfuric acid (1.6 mL) was added iodine (1.32 g) and sodium iodate (0.55 g). The mixture was heated at 75° C. for 2.5 hours and then stirred at rt overnight. Water (100 mL) was added, and the precipitated 5-iodo-4-methyl-3-nitro-2-pyridone was collected by filtration (2.97 g, 82%).

Herkunft & Nachweise