Hydrochloric Acid → 2-Ethoxy-4-aminobenzoic acid

HRID 1005925

Reaktionsgleichung

Reaktionsgleichung von HRID 1005925
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH:14]C(=O)C)[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7])[CH3:2].Cl>[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7])[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 6034Ethopabate

Produkt 1

HCID 101763852-Ethoxy-4-aminobenzoic acidAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A suspension of methyl 2-ethoxy-4-acetamidobenzoate (50 g, 211 mmol) in aqueous solution of NaOH (15% W/W, 200 ml) was gently refluxed for 16 hours. The resulting pale brown solution was allowed to cool to room temperature and then further cooled in an ice water bath. Concentrated HCl (37% w/w) was added until the solution reached a pH of 6. The solid precipitated from the solution was filtered under vacuum, dried at 50° C. to give 38.3 g of the title compound (yield 100%).

Aufarbeitung

  1. temperaturewas gently refluxed for 16 hours
  2. temperaturefurther cooled in an ice water bath
  3. customThe solid precipitated from the solution
  4. filtrationwas filtered under vacuum
  5. customdried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-852b7778be63425b98a64a8040d1bc8a
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06787550B1

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