Hydrochloric Acid → 2-Benzhydrylpiperazine dihydrochloride

HRID 1006316Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1006316
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12](C)[CH:11]([CH:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1.C(O)C>[ClH:1].[ClH:1].[CH:16]([CH:11]1[CH2:10][NH:9][CH2:14][CH2:13][NH:12]1)([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 226745434-Tert-butoxycarbonyl-2-benzhydryl-1-methylpiperazine

Produkt 1

HCID 226747432-Benzhydrylpiperazine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4N Hydrogen chloride in 1,4-dioxane (44 ml) was added to a solution of 4-tert-butoxycarbonyl-2-benzhydryl-1-methylpiperazine (6.5 g) in ethanol (33 ml) under ice-cooling over 30 minutes. The mixture was stirred at room temperature for 4 hours and evaporated under reduced pressure. The residue was triturated with diisopropyl ether and the resulting solid was collected by filtration to give 2-benzhydrylpiperazine dihydrochloride (6.02 g) as a powder.

Aufarbeitung

  1. temperaturecooling over 30 minutes
  2. customevaporated under reduced pressure
  3. customThe residue was triturated with diisopropyl ether
  4. filtrationthe resulting solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-e733c5bed9424b8b95a6b6861fe0742c
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06787543B2

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