Methanol → methyl (2S)-piperidine-2-carboxylate hydrochloride

HRID 1006327

Reaktionsgleichung

S(Cl)([Cl:3])=O.[CH2:5]1[CH2:10][C@@H:9]([C:11]([OH:13])=[O:12])[NH:8][CH2:7][CH2:6]1.[CH3:14]O>>[ClH:3].[CH3:14][O:12][C:11]([C@@H:9]1[CH2:10][CH2:5][CH2:6][CH2:7][NH:8]1)=[O:13]

Komponenten

Edukt 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 439227Pipecolic acid, (-)-

Produkt 1

HCID 13246232methyl (2S)-piperidine-2-carboxylate hydrochloride

Reaktionsbedingungen

Temperatur: 55 °C

Versuchsvorschrift

Thionyl chloride (0.58 ml) was added dropwise to a solution of L-pipecolinic acid (450 mg) in methanol at room temperature. The reaction mixture was stirred at 55° C. for 2 hours. The whole mixture was evaporated under reduced pressure to give (2S)-piperidine-2-carboxylic acid methyl ester hydrochloride as a colorless oil.

Aufarbeitung

customThe whole mixture was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-6a6deb3a16944022b212e5e35fcbc918
Quelldatensatz: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06787543B2

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