1-(Bromomethyl)-2,3-difluoro-benzene → HCID 178508256, Verbindung

HRID 1006492

Reaktionsgleichung

Reaktionsgleichung von HRID 1006492
CC(C)([O-])C.[K+].[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[NH:14][C:13](=[S:17])[NH:12][C:11]=2[N:18]=1.[F:19][C:20]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br>CS(C)=O>[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[N:14]=[C:13]([S:17][CH2:22][C:21]3[CH:24]=[CH:25][CH:26]=[C:27]([F:28])[C:20]=3[F:19])[NH:12][C:11]=2[N:18]=1

Komponenten

5

Edukt 3

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 114583092-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-oneHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 178508256HCID 178508256, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Potassium t-butoxide solution (0.45 ml of 1M solution in tetrahydrofuran) was added to a stirred solution of 2-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-one (0.09 g) [Cited: Indian J. Chem., Sect. B (1989), 28B(11), 964-5.] and 2,3-difluorobenzyl bromide in dimethyl sulphoxide (2 ml). After stirring for 3 days, the reaction mixture was poured onto water to give and the subtitle compound, isolated by filtration.

Aufarbeitung

  1. additionthe reaction mixture was poured onto water
  2. customto give

Quellen und Nachweise

ORD-Eintrag
ord-a7a75b0f10e0404594d76a55bd7a4c8b
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06790850B1

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