N-(4-Chloro-2-nitrophenyl)benzenesulfonamide → 2-Phenylsulfonylamino-5-chloroaniline

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 2-phenylsulfonylamino-5-chloro-1-nitrobenzene (172 mg; prepared in Reference Example 11.) in acetic acid (4 ml), reduced iron powder (154 mg) was added at room temperature under an atmosphere of argon. The suspension was stirred for 2 hours at 120° C. The reaction suspension was diluted with ethyl acetate and filtered. The filtrate was concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (AcOEt-hexane) to give the title compound (92 mg) having the following physical data.

Herkunft & Nachweise