Hydrochloric Acid → 2,3-Difluoro-4-methoxybenzoic acid

HRID 1007344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1007344
[OH-].[Na+].[F:3][C:4]1[C:13]([F:14])=[C:12]([O:15][CH3:16])[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7].C1COCC1.Cl>CO>[F:3][C:4]1[C:13]([F:14])=[C:12]([O:15][CH3:16])[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21907384Methyl 2,3-difluoro-4-methoxybenzoate

Produkt 1

HCID 36116822,3-Difluoro-4-methoxybenzoic acidAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium hydroxide (2N, 50 mL) was added into a mixture of methyl 2,3-difluoro-4-methoxybenzoate (10.0 g, 49.5 mmol), THF (100 mL) and MeOH (100 mL). The mixture was stirred at room temperature for 6 h, and acidified with HCl (2N). The precipitated solid was filtered off, washed with water and dried to give a white solid (8.9 g, 96% yield, m.p. 194-196° C.); MS m/e 187 (M−H)+.

Aufarbeitung

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-92de0c71a3244795bd38ee55e949b83d
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06794403B2

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