Oxalic Acid → N-[3-(2-benzo[b]thiophen-5-ylethoxy)propyl]-N,N-diethylamine oxalate

HRID 1007900

Reaktionsgleichung

Reaktionsgleichung von HRID 1007900
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH:8]=[CH:9][C:2]1=2.[C:21]([OH:26])(=[O:25])[C:22]([OH:24])=[O:23]>C(OCC)(=O)C>[C:21]([OH:26])(=[O:25])[C:22]([OH:24])=[O:23].[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[CH:8]=[CH:9][C:2]1=2

Komponenten

4

Edukt 2

HCID 971Oxalic AcidHCID 22666289N-[3-(2-benzo[b]thiophen-5-ylethoxy)propyl]-N,N-diethylamine

Produkt 1

HCID 22666288N-[3-(2-benzo[b]thiophen-5-ylethoxy)propyl]-N,N-diethylamine oxalateAusbeute 78,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

In 2 mL of ethyl acetate is dissolved 0.46 g of N-[3-(2-benzo[b]thiophen-5-ylethoxy)propyl]-N,N-diethylamine, to which is added 2.5 mL of a solution of 0.15 g of oxalic acid in ethyl acetate. The resulting mixture is stirred at ambient temperature for 2 hours. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.47 g of N-[3-(2-benzo[b]thiophen-5-ylethoxy)propyl]-N,N-diethylamine oxalate.

Aufarbeitung

  1. filtrationThe deposited crystal is collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1f0ea39af0b748bab5f24a13e5e63a32
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06797726B1

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