2-Chloro-3-nitropyridine → 3-Nitro-2-phenoxypyridine
Reaktionsgleichung
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[O-:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Na+]>>[N+:8]([C:7]1[C:2]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]Komponenten
3
Versuchsvorschrift
In step (6) of Reaction Scheme II, a 2-chloro-3-nitropyridine of Formula XXV is reacted with sodium phenoxide to provide a 3-nitro-2-phenoxypyridine of Formula XXVI. Phenol is reacted with sodium hydride in a suitable solvent such as tetrahydrofuran to form the phenoxide. The phenoxide is then reacted at an elevated temperature with a compound of Formula XXV.
Aufarbeitung
- customIn step (6) of Reaction Scheme II
Quellen und Nachweise
- ORD-Eintrag
- ord-298bda56873e4b86b6ee58a1adaddc2b
- Quelldatensatz
- uspto-grants-2004_09
- Patentnummer
- US06797718B2
Notizen zur Reaktion
Wird geladen…