Reaktionsgleichung
Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]#[C:11][CH3:12])[N:5]=[CH:4][N:3]=1.[F:13][C:14]([F:22])([F:21])[CH:15]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]1>>[CH2:9]([O:8][C:6]1[CH:7]=[C:2]([N:17]2[CH2:18][CH2:19][CH2:20][CH:15]([C:14]([F:22])([F:21])[F:13])[CH2:16]2)[N:3]=[CH:4][N:5]=1)[C:10]#[C:11][CH3:12]Komponenten
3
Versuchsvorschrift
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.25 g of 3-trifluoromethylpiperidine were mixed and left for 10 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.30 g of 4-(2-butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine (hereinafter, referred to as Compound (24)).
Quellen und Nachweise
- ORD-Eintrag
- ord-fdf92ab7964b4e9a82d13494eee4ee19
- Quelldatensatz
- uspto-grants-2011_07
- Patentnummer
- US07973028B2
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