4-Benzyloxy-2-methoxyphenylacetic acid → N-(5-ethyl-1H-pyrazol-3-yl)-2-(4-benzyloxy-2-methoxyphenyl)acetamide

Beteiligte Stoffe

Reaktionsschritte

Using an analogous procedure to that described in the portion of Example 17 that is concerned with the preparation of starting materials, 2-(4-benzyloxy-2-methoxyphenyl)acetic acid was reacted at 75° C. for 3 hours with 3-amino-5-ethylpyrazole to give N-(5-ethylpyrazol-3-yl)-2-(4-benzyloxy-2-methoxyphenyl)acetamide; 1H NMR: (DMSOd6) 1.15 (t, 3H), 2.55 (q, 2H), 3.48 (s, 2H), 3.73 (s, 3H), 5.09 (s, 2H), 6.24 (s, 1H), 6.54 (m, 1H), 6.62 (d, 1H), 7.06 (d, 1H), 7.33 (t, 1H), 7.39 (m, 2H), 7.45 (m, 2H), 10.15 (br s, 1H); Mass Spectrum: M+H+ 366; which material was hydrogenated to give N-(5-ethylpyrazol-3-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide; 1H NMR: (DMSOd6) 1.15 (t, 3H), 2.53 (q, 2H), 3.43 (s, 2H), 3.68 (s, 3H), 6.24 (br s, 1H), 6.28 (m, 1H), 6.37 (d, 1H), 6.93 (d, 1H), 9.29 (br s, 1H), 10.09 (br s, 1H); Mass Spectrum: M+H+ 276.

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