Trifluoroacetic acid → HCID 178493996, Verbindung

HRID 1010959Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1010959
[CH3:1][CH:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:21][CH3:22])[N:12]2C2CCCCO2)=[C:8]([NH2:23])[N:7]=1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:21][CH3:22])[NH:12]2)=[C:8]([NH2:23])[N:7]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57699783HCID 57699783, Verbindung

Produkt 1

HCID 178493996HCID 178493996, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-[(3-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (210 mg) in dry MeOH (2.1 mL) was added TFA (0.21 ml) and the mixture was stirred at room temperature for 24 h. The reaction was concentrated in vacuo to give a yellow residue which was triturated with Et2O (15 mL) and filtered under reduced pressure to give the title compound as an off-white solid (143 mg).

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O (15 mL)
  4. filtrationfiltered under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bb1f24f3bd604e7887cfaed5fefa6890
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977344B2

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