Trifluoroacetic acid → HCID 178447009, Verbindung

HRID 1010970Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1010970
[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]2C2CCCCO2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5].[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[NH:13]2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 576997022-[(1-Methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

Produkt 1

HCID 178447009HCID 178447009, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-[(1-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (313 mg) in dry MeOH (3.13 mL) was added TFA (0.313 mL) and the mixture was stirred at room temperature for 48 h. The reaction mixture was concentrated in vacuo to give a yellow residue which was triturated with Et2O and filtered to give the title compound as an off-white solid (218 mg).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O
  4. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-5c8bbd0f9df4412bb9bcfeb4618ca128
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977344B2

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